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Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN101:14

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Treating arylamines with nitrous acid gives aryldiazonium salts that are effective substrates in nucleophilic aromatic substitution reactions. The diazonio group in these salts can be easily displaced by different nucleophiles, yielding a wide variety of substituted benzenes. The leaving group departs as nitrogen gas, and this easy elimination is the driving force for the substitution reaction.
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
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Electrophilic Addition to Alkynes: Halogenation02:38

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Introduction
Halogenation is another class of electrophilic addition reactions where a halogen molecule gets added across a π bond. In alkynes, the presence of two π bonds allows for the addition of two equivalents of halogens (bromine or chlorine). The addition of the first halogen molecule forms a trans-dihaloalkene as the major product and the cis isomer as the minor product. Subsequent addition of the second equivalent yields the tetrahalide.
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Preparation of Alkynes: Alkylation Reaction02:27

Preparation of Alkynes: Alkylation Reaction

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Introduction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.
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Preparation of 1° Amines: Azide Synthesis01:22

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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions01:20

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Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
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Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)01:30

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Nucleophilic substitution in aromatic compounds is feasible in substrates bearing strong electron-withdrawing substituents positioned ortho or para to the leaving group. The reaction proceeds via two steps: the addition of the nucleophile and the elimination of the leaving group.
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between...
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Las arsinas α-catiónicas: síntesis, estructura, reactividad y aplicaciones

Jonathan W Dube1,2, Yiying Zheng2, Walter Thiel2

  • 1Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen , Tammannstraße 2, 37077 Göttingen, Germany.

Journal of the American Chemical Society
|May 24, 2016
PubMed
Resumen
Este resumen es generado por máquina.

Se sintetizaron nuevas arsinas catiónicas y muestran propiedades electrónicas únicas. Estos nuevos ligandos de arsina demuestran una actividad notable en las reacciones de cicloisomerización catalizadas por platino, lo que marca una primicia en la catálisis.

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Área de la Ciencia:

  • Química organometálica
  • Catálisis
  • Química sintética

Sus antecedentes:

  • Las arsinas catiónicas son ligandos versátiles en la química de la coordinación.
  • Comprender sus propiedades electrónicas es crucial para el diseño de catalizadores.
  • Explorar nuevas arquitecturas de ligandos puede desbloquear una nueva reactividad.

Objetivo del estudio:

  • Sintetizar y caracterizar nuevas arsinas α-catiónicas con diversos sustituyentes.
  • Investigar las propiedades electrónicas y de coordinación de estos nuevos ligandos de arsina.
  • Para evaluar su rendimiento en reacciones catalizadas por metales, específicamente en la catálisis Pt (II).

Principales métodos:

  • Síntesis de imidazolio, ciclopropenio, formamidinio y arsinas sustituidas por piridinio.
  • Caracterización mediante espectroscopia de infrarrojos y cálculos de la teoría funcional de la densidad (DFT).
  • Exploración de la química de coordinación con varios centros metálicos y la reactividad con los oxidantes.
  • Aplicación en la cicloisomerización catalizada por platino de las eninas.

Principales resultados:

  • Síntesis exitosa de arsinas catiónicas estructuralmente diferenciadas por vías escalables.
  • Capacidades similares de liberación de electrones sigma pero propiedades de aceptor pi variables basadas en el grupo catiónico.
  • Se ha demostrado la coordinación con los centros metálicos y la formación de especies catiónicas de As (V).
  • Desarrollo de un nuevo catalizador Pt (II) que presenta una alta actividad en la cicloisomerización.

Conclusiones:

  • Las arsinas α-catiónicas sintetizadas poseen propiedades electrónicas sintonizables.
  • Estos ligandos son efectivos para estabilizar los centros metálicos y mediar las transformaciones catalíticas.
  • Este trabajo introduce la primera aplicación de ligandos de arsina α-catiónica en catálisis, abriendo nuevas vías para el desarrollo de catalizadores.