Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.0K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.0K
Immunological Memory01:23

Immunological Memory

17.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.7K
Mitochondrial Membranes01:45

Mitochondrial Membranes

17.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.6K
Mitochondrial Membranes01:45

Mitochondrial Membranes

2.3K
2.3K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.9K
T Cell Types and Functions01:24

T Cell Types and Functions

3.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.1K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets.

The EMBO journal·2026
Same author

Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease.

Translational neurodegeneration·2026
Same author

Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway.

Science advances·2026
Same author

Small-molecule binding-site discovery using silyl ether-enabled chemoproteomics.

Nature chemistry·2026
Same author

Activation of the protective arm of renin-angiotensin system enhances mitochondrial turnover improving respiration and decreasing integrated stress response in a human Complex III deficiency model.

bioRxiv : the preprint server for biology·2026
Same author

Chronic cold exposure induces plasticity of mitochondrial calcium uptake in beige and brown fat of UCP1-deficient mice.

bioRxiv : the preprint server for biology·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Ver todos los artículos relacionados
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: Mar 18, 2026

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
06:55

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

4.4K

Redes mitocondriales en la memoria de las células T

Marc Liesa1, Orian S Shirihai1

  • 1Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Cell
|July 2, 2016
PubMed
Resumen
Este resumen es generado por máquina.

Los linfocitos T alteran sus necesidades energéticas en función de su función, lo que representa un desafío bioenergético. Buck y otros. Descubrieron que los cambios en la forma de las mitocondrias están relacionados con las decisiones del destino de las células T.

Más Videos Relacionados

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

1.3K
Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

13.9K

Videos de Experimentos Relacionados

Last Updated: Mar 18, 2026

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
06:55

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

4.4K
Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

1.3K
Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

13.9K

Área de la Ciencia:

  • Biología celular
  • Inmunología
  • Biología mitocondrial

Sus antecedentes:

  • Los linfocitos T exhiben una plasticidad metabólica significativa, adaptando la demanda de ATP y la utilización de nutrientes para cumplir diversas funciones funcionales, como la memoria T y las células efectoras T.
  • Esta adaptación metabólica presenta un desafío bioenergético considerable para las mitocondrias dentro de las células T, impactando la remodelación celular.
  • Comprender estos cambios bioenergéticos es crucial para comprender la diferenciación y la función de las células T.

Objetivo del estudio:

  • Para investigar la relación entre la dinámica mitocondrial y la determinación del destino de las células T.
  • Explorar cómo los desafíos bioenergéticos influyen en la remodelación y la especialización funcional de las células T.
  • Para aclarar el papel de la morfología mitocondrial en la diferenciación de células T.

Principales métodos:

  • Análisis de los estados metabólicos de los linfocitos T bajo diferentes demandas funcionales.
  • Evaluación de la morfología mitocondrial en diferentes subconjuntos de células T.
  • Estudios de correlación que vinculan los cambios en la forma mitocondrial con los marcadores del destino de las células T.

Principales resultados:

  • Los linfocitos T muestran alteraciones sustanciales en la demanda de ATP y la utilización de nutrientes.
  • Se observaron cambios significativos en la forma mitocondrial y se relacionaron con destinos distintos de las células T.
  • La remodelación mitocondrial surge como un factor clave en la elección del destino de las células T.

Conclusiones:

  • La forma mitocondrial es un determinante crítico en las decisiones del destino de las células T.
  • Las demandas bioenergéticas de las funciones de las células T requieren adaptación mitocondrial.
  • Este estudio proporciona nuevos conocimientos sobre la interacción entre la dinámica mitocondrial y la diferenciación celular inmune.