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Una perspectiva microbiana de la biología del desarrollo humano
Mark R Charbonneau1,2, Laura V Blanton1,2, Daniel B DiGiulio3,4
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Nature
|July 8, 2016
Resumen
El desarrollo humano incluye comunidades microbianas, que ofrecen nuevas formas de definir el crecimiento saludable y prevenir enfermedades. Establecimiento
Área de la Ciencia:
- Microbiología
- Desarrollo humano
- Investigación del microbioma
Sus antecedentes:
- El desarrollo humano tradicionalmente se centra en el crecimiento celular y de órganos.
- Las comunidades microbianas asociadas con los humanos juegan un papel crucial, pero a menudo pasado por alto, en el desarrollo.
- Comprender el microbioma es clave para una visión holística del crecimiento humano.
Objetivo del estudio:
- Destacar la importancia de las comunidades microbianas en el desarrollo humano.
- Proponer nuevas estrategias para la prevención y el tratamiento de enfermedades a través de una lente microbiana.
- Abogar por nuevas infraestructuras de investigación para estudiar el desarrollo microbiano.
Principales métodos:
- Este estudio es una revisión conceptual y basada en propuestas.
- Sintetiza el conocimiento existente sobre el microbioma humano y el desarrollo.
- Se pide el establecimiento de iniciativas de investigación específicas.
Principales resultados:
- Una perspectiva microbiana refina las definiciones de crecimiento prenatal y postnatal saludable.
- La integración de la investigación sobre el microbioma puede conducir a estrategias innovadoras de prevención y tratamiento de enfermedades.
- Los cambios globales en el estilo de vida y los patrones de enfermedad requieren nuevos enfoques de investigación.
Conclusiones:
- El microbioma humano es integral para el desarrollo humano.
- El establecimiento de "observatorios microbianos humanos" es crucial para estudiar el desarrollo de las comunidades microbianas.
- La investigación debe centrarse en diversas cohortes de nacimiento para comprender las variaciones en el desarrollo microbiano.
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