Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

82
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
82
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

72
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
72
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

297
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
297
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

192
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
192
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

73
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
73
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

74
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
74

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling.

CPT: pharmacometrics & systems pharmacology·2026
Same author

Unravelling the Intrinsic Reactivity and Colloidal Instability in Tin-Based Halide Perovskite Precursor Solutions.

Angewandte Chemie (International ed. in English)·2026
Same author

Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025.

CPT: pharmacometrics & systems pharmacology·2026
Same author

Advancing Quantitative <sup>31</sup>P NMR Spectroscopy for Reliable Thiol Group Analysis.

ACS macro letters·2026
Same author

Nanosized Li<sub>2</sub>S-Loaded Polar Porous Carbon Nanofibers as Self-Supporting Electrodes in Anode-Free Lithium-Sulfur Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Small-Angle X-ray Scattering Monitoring of Porosity Evolution in Iron-Nitrogen-Carbon Electrocatalysts.

ACS nano·2025

Video Experimental Relacionado

Updated: Mar 18, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.1K

El avance de los aditivos de formulación de medicamentos hacia aditivos de precisión con una capa intermedia de

Sebastian Wieczorek, André Dallmann, Zdravko Kochovski1

  • 1Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie , Hahn-Meitner-Platz 1, Berlin, Germany.

Journal of the American Chemical Society
|July 12, 2016
PubMed
Resumen

Los nuevos aditivos para la formulación de fármacos que utilizan ácido palmítico-polietilenglicol (Pal-PEG) y un péptido específico controlan con precisión la liberación del fármaco. Esta innovación mejora la solubilidad y la cinética de administración de fármacos para aplicaciones terapéuticas avanzadas.

Más Videos Relacionados

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.9K
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.8K

Videos de Experimentos Relacionados

Last Updated: Mar 18, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.1K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.9K
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.8K

Área de la Ciencia:

  • Sistemas de administración de medicamentos
  • Química de los polímeros
  • Química del bioconjugado

Sus antecedentes:

  • El desarrollo de sistemas eficaces de administración de fármacos es crucial para el éxito terapéutico.
  • Las formulaciones actuales a menudo enfrentan desafíos con la solubilidad, la estabilidad y la liberación controlada de medicamentos.
  • El polietilenglicol (PEG) es ampliamente utilizado por su solubilidad y biocompatibilidad, mientras que los componentes hidrofóbicos pueden ayudar a la carga de fármacos.

Objetivo del estudio:

  • Desarrollar nuevos aditivos para formulaciones anfifílicas para un control preciso de los perfiles de liberación de fármacos.
  • Crear un sistema que mejore la solubilidad de los medicamentos y logre una alta capacidad de carga de medicamentos.
  • Investigar el papel de un péptido personalizado en la modulación de la cinética de activación del fármaco.

Principales métodos:

  • Aditivos anfifílicos sintetizados a base de polietileno glicol modificado con ácido palmítico (Pal-PEG).
  • Incorpora un péptido de unión al fármaco seleccionado mediante métodos combinatorios en la interfaz hidrofóbico-hidrofílico.
  • Formulado un fármaco fotosensibilizador utilizando los aditivos desarrollados.
  • Carga de fármaco, solubilidad y cinética de liberación evaluadas, incluida la modulación de activación.

Principales resultados:

  • Los aditivos Pal-PEG lograron altas cargas útiles de fármacos, acercándose a una proporción de 1:1.
  • La formulación hizo con éxito que un fotosensibilizador fuera soluble en agua.
  • El ajuste fino de la capa de interfaz de péptidos permitió una cinética de activación de fármacos ajustable.
  • El péptido permitió una modulación precisa de los perfiles de liberación del fármaco.

Conclusiones:

  • Los aditivos a base de Pal-PEG con péptidos adaptados ofrecen una plataforma versátil para la formulación de fármacos avanzados.
  • Este enfoque proporciona una mayor solubilidad, una alta carga de fármaco y una cinética de liberación / activación ajustable.
  • El sistema es prometedor para mejorar la eficacia y la administración de varios agentes terapéuticos, incluidos los fotosensibilizantes.