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Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
Published on: April 22, 2015
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El toque problemático del autismo
Alexander H Tuttle1, Victoria B Bartsch1, Mark J Zylka1
1Department of Cell Biology and Physiology, UNC Neuroscience Center, The Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cell
|July 16, 2016
Resumen
Los déficits en las neuronas sensibles al tacto afectan el comportamiento social y la ansiedad en modelos de ratón de autismo y síndrome de Rett. Esto sugiere que el sistema nervioso periférico puede desempeñar un papel en los síntomas centrales del autismo.
Área de la Ciencia:
- La neurociencia
- Biología del desarrollo
- La genética
Sus antecedentes:
- El trastorno del espectro autista (TEA) y el síndrome de Rett (RTT) son trastornos complejos del desarrollo neurológico.
- Los síntomas principales incluyen déficits de interacción social y ansiedad.
- Los mecanismos biológicos subyacentes no se comprenden completamente.
Objetivo del estudio:
- Investigar el papel de las neuronas somatosensoriales en el comportamiento social y la ansiedad.
- Explorar los vínculos potenciales entre la disfunción del sistema nervioso periférico y los fenotipos de autismo/RTT.
Principales métodos:
- Utilizó modelos de ratón genéticamente diseñados para exhibir características de autismo o síndrome de Rett.
- Evaluó comportamientos de interacción social y respuestas similares a la ansiedad.
- Examinó el desarrollo y la función de las neuronas somatosensoriales.
Principales resultados:
- Demostró que los déficits en las neuronas somatosensoriales sensibles al tacto se correlacionan significativamente con la interacción social deteriorada.
- Se observó un claro vínculo entre la disfunción de las neuronas somatosensoriales y el aumento de los fenotipos de ansiedad en estos modelos.
- Pruebas de desarrollo o función anormal dentro del sistema nervioso periférico.
Conclusiones:
- Los déficits de las neuronas somatosensoriales sensitivas al tacto están implicados en los síntomas sociales y relacionados con la ansiedad del autismo y el síndrome de Rett.
- Estos hallazgos destacan el sistema nervioso periférico como un origen potencial para algunos síntomas centrales del autismo.
- Sugiere nuevas dianas terapéuticas dentro del sistema nervioso periférico para trastornos del desarrollo neurológico.
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