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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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Una revisión de la celulitis

Adam B Raff1, Daniela Kroshinsky1

  • 1Harvard Medical School, Massachusetts General Hospital, Boston.

JAMA
|July 20, 2016
PubMed
Resumen
Este resumen es generado por máquina.

La celulitis, una infección común de la piel, se diagnostica clínicamente. El tratamiento inicial se dirige a Streptococcus y Staphylococcus aureus sensibles a la meticilina, con MRSA considerado para pacientes de alto riesgo. Abordar los factores de riesgo previene la recurrencia.

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Área de la Ciencia:

  • Dermatología
  • Enfermedades infecciosas
  • Salud pública

Sus antecedentes:

  • La celulitis es una infección bacteriana frecuente de la piel que afecta a la dermis profunda y al tejido subcutáneo.
  • Causa una carga significativa de atención médica, con más de 650,000 admisiones anuales en los Estados Unidos y costos sustanciales de atención ambulatoria.
  • Las bacterias causantes a menudo no se identifican debido a la naturaleza no cultivable en la mayoría de los casos.

Objetivo del estudio:

  • Para delinear los criterios de diagnóstico para la celulitis.
  • Proporcionar directrices de tratamiento basadas en la evidencia para la celulitis.
  • Hacer hincapié en la importancia de abordar los factores predisponentes para la prevención de la recurrencia.

Principales métodos:

  • El diagnóstico se basa en la presentación clínica, incluido el eritema, el calor, la sensibilidad y la hinchazón.
  • La selección empírica de antibióticos tiene en cuenta patógenos comunes como Streptococcus y Staphylococcus aureus.
  • La duración del tratamiento es típicamente de cinco días, con extensiones basadas en la respuesta clínica.

Principales resultados:

  • Streptococcus y Staphylococcus aureus son los patógenos identificados más comunes en la celulitis.
  • El tratamiento debe cubrir inicialmente el S. aureus sensible a la meticilina (MSSA), ampliándose al S. aureus resistente a la meticilina (MRSA) para las poblaciones en riesgo.
  • Cinco días de tratamiento con antibióticos suelen ser suficientes, con ciclos más largos para los síntomas persistentes.

Conclusiones:

  • El diagnóstico de la celulitis es principalmente clínico, basado en la historia clínica y el examen físico del paciente.
  • El tratamiento estándar consiste en dirigirse a Streptococcus y MSSA.
  • El fracaso del tratamiento requiere una reevaluación para detectar organismos resistentes, condiciones de imitación o problemas de salud subyacentes.