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Reversión de la latencia y aclaramiento viral para curar el VIH-1

David M Margolis¹, J Victor Garcia², Daria J Hazuda³

¹University of North Carolina HIV Cure Center, Department of Medicine, and Center for AIDS Research, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. dmargo@med.unc.edu.

Science (New York, N.Y.)

|July 28, 2016

Resumen

Los investigadores están desarrollando una cura para el virus de la inmunodeficiencia humana tipo 1 (VIH-1) mediante la combinación de la terapia antirretroviral con estrategias de refuerzo inmunológico para eliminar el virus latente. Este enfoque ofrece optimismo para una cura funcional y la reducción de la pandemia del VIH

Área de la Ciencia:

Virología
Inmunología
Salud pública

Sus antecedentes:

Los esfuerzos mundiales para combatir la infección por el VIH-1 ahora incluyen la búsqueda de una cura.
Las estrategias actuales combinan la supresión antirretroviral con terapias dirigidas al virus latente.

Objetivo del estudio:

Para explorar una cura para el VIH-1 mediante la erradicación de los reservorios virales latentes.
Evaluar la combinación de estrategias de reversión de la latencia y de depuración para la erradicación del VIH.

Principales métodos:

La supresión antirretroviral combinada con terapias dirigidas para inducir la expresión del antígeno viral.
Inmunoterapia dirigida a eliminar la infección latente por el VIH-1.
Pruebas emparejadas de estrategias de reversión de la latencia y de depuración.

Principales resultados:

Se ha iniciado la prueba de estrategias combinadas de reversión de la latencia y de depuración.
Todavía pueden surgir obstáculos potenciales para la erradicación del VIH.
Los avances en la terapia antirretroviral de acción prolongada y la prevención son prometedores.

Conclusiones:

Una cura para el SIDA es una meta factible a través de estrategias terapéuticas combinadas.
Existe optimismo en cuanto a los efectos sinérgicos de las nuevas terapias y métodos de prevención.
Se espera que estos avances reduzcan significativamente el impacto social de la pandemia del VIH.

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