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Videos de Conceptos Relacionados

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

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The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
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Long-term Depression01:03

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:05

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Repressed Memory01:16

Repressed Memory

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Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
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Higher Mental Functions of Brain: Learning and Memory01:26

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Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
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Interference and Decay01:16

Interference and Decay

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Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
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A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
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Comentario sobre "Múltiples mecanismos represivos en el hipocampo durante la formación de la memoria"

Rebecca S Mathew, Hillary Mullan, Jan Krzysztof Blusztajn

    Science (New York, N.Y.)
    |August 3, 2016
    PubMed
    Resumen

    La represión genética en el cerebro después del condicionamiento del miedo impacta la memoria. Este estudio sugiere que la contaminación del plexo coroideo en muestras del hipocampo puede afectar los hallazgos sobre la expresión génica relacionada con la formación de la memoria.

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    Área de la Ciencia:

    • La neurociencia
    • Biología molecular
    • La genética

    Sus antecedentes:

    • La represión genética está implicada en la formación de la memoria del hipocampo después del condicionamiento del miedo contextual.
    • Estudios anteriores sugieren que genes candidatos específicos están involucrados en este proceso.

    Objetivo del estudio:

    • Investigar los patrones de expresión de los genes candidatos después del condicionamiento contextual del miedo.
    • Para validar el papel de la represión genética en la formación de la memoria del hipocampo.

    Principales métodos:

    • Análisis de los niveles de expresión génica en los tejidos del hipocampo y del plexo coroideo.
    • Comparación de perfiles de expresión génica en diferentes momentos después del condicionamiento del miedo.

    Principales resultados:

    • Se observó una baja expresión de los genes candidatos principales en muestras del hipocampo.
    • Detectamos una expresión robusta de estos genes en el plexo coroideo.
    • Encontramos represión genética 4 horas después del acondicionamiento.

    Conclusiones:

    • El estudio sugiere una posible contaminación de las muestras del hipocampo con ARN mensajero del plexo coroide.
    • Esta contaminación puede confundir la interpretación de los datos de expresión génica relacionados con la formación de la memoria en el hipocampo.