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Los macrófagos del riñón: su posición única resuelve un problema complejo
Miriam Berry1, Menna R Clatworthy1
1University of Cambridge Department of Medicine, Molecular Immunity Unit, Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Cell
|August 13, 2016
Resumen
Los investigadores identificaron una nueva vía específica del riñón para el transporte del complejo inmune a través de las paredes de los vasos sanguíneos. Este mecanismo activa los macrófagos residentes, impactando las enfermedades renales mediadas por el complejo inmune como el lupus.
Área de la Ciencia:
- Nefrología
- Inmunología
- Patología
Sus antecedentes:
- Las enfermedades mediadas por el complejo inmunológico afectan con frecuencia a los riñones, influyendo significativamente en el pronóstico del paciente.
- El lupus eritematoso sistémico es un excelente ejemplo de tal condición en la que la afectación renal es común.
Objetivo del estudio:
- Para aclarar un mecanismo específico del riñón para el transporte de pequeños complejos inmunes.
- Para entender cómo este transporte activa los macrófagos residentes dentro del riñón.
Principales métodos:
- Investigó el transporte transendotelial de complejos inmunes en el riñón.
- Examinó la activación de los macrófagos residentes en el tejido por estos complejos.
Principales resultados:
- Propuso un nuevo mecanismo específico para el riñón para el transporte transendotelial de pequeños complejos inmunes.
- Se demostró que este transporte activa los macrófagos residentes en el tejido estratégicamente posicionados.
Conclusiones:
- Esta vía específica del riñón ofrece nuevos conocimientos sobre la patogénesis de las enfermedades renales mediadas por el complejo inmunológico.
- Dirigirse a este mecanismo podría representar una estrategia terapéutica futura para enfermedades como el lupus nefritis.
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