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Updated: Mar 16, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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Las diversas vías de activación de los GPCR de clase A convergen cerca de la región de acoplamiento a la proteína G

A J Venkatakrishnan, Xavier Deupi, Guillaume Lebon

    Nature
    |August 16, 2016
    PubMed
    Resumen

    Los receptores acoplados a proteínas G de clase A (GPCR) comparten una convergencia común en la vía de activación. Este mecanismo conservado, que involucra hélices transmembrana específicas, explica cómo diversos ligandos activan estos objetivos farmacológicos cruciales.

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