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Un catalizador de nanopartículas metálicas orgánicas de cadena única altamente eficiente para las reacciones de

Yugang Bai¹, Xinxin Feng¹, Hang Xing^1,2

¹Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.

Journal of the American Chemical Society

|August 17, 2016

Resumen

Las nanopartículas metálicas orgánicas (MONP) que contienen cobre catalizan eficientemente la química del clic en el agua. Estos MONP verdes de baja toxicidad pueden sintetizar moléculas dentro de las células, actuando como fábricas moleculares a nanoescala.

Área de la Ciencia:

Ciencias de los materiales
Nanotecnología
Catálisis

Sus antecedentes:

Las nanopartículas metálicas orgánicas (MONP) que contienen cobre se sintetizan utilizando un nuevo método de enlace cruzado.
El enlace cruzado intramolecular de poliolefinas en agua constituye la base de la síntesis de MONP.

Objetivo del estudio:

Desarrollar catalizadores eficientes y ecológicos para la química del clic de alquina-azida.
Para explorar el potencial de los MONP como sintetizadores moleculares intracelulares.

Principales métodos:

Síntesis de MONP que contienen cobre mediante el enlace cruzado de poliolefinas mediado por Cu (II).
Reducción in situ a Cu ((I) -MONP utilizando el ascorbato de sodio.
Aplicación de Cu(I) -MONP como catalizadores para la química del clic en medios acuosos.

Principales resultados:

Se ha logrado una catálisis supramolecular altamente eficiente para las reacciones de clic de alquina-azida a bajas concentraciones de catalizador (niveles de ppm).
Se ha demostrado una baja toxicidad y bajas cargas metálicas para los MONP sintetizados.
Demostró la capacidad de los Cu-MONPs para entrar en las células y realizar una química de clic biocompatible.

Conclusiones:

Desarrollado conveniente, catalizadores verdes para hacer clic en la química del agua.
Los Cu-MONP establecidos como eficaces sintetizadores moleculares a nanoescala intracelular.

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