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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Alfred G. Knudson (1922-2016) fue uno de los

Carlo M Croce1

  • 1Department of Cancer Biology and Genetics, Ohio State University, Columbus, Ohio, USA. He met Alfred Knudson in the 1970s at the Wistar Institute in Philadelphia.

Nature
|August 26, 2016
PubMed
Resumen

No abstract available in PubMed .

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