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Localization of the Locus Coeruleus in the Mouse Brain
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Locus coeruleus y consolidación dopaminérgica de la memoria cotidiana
Tomonori Takeuchi1, Adrian J Duszkiewicz1, Alex Sonneborn2
1Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
Nature
|September 8, 2016
Resumen
La novedad mejora la retención de la memoria. Los investigadores descubrieron que las neuronas en el locus coeruleus, no en el área tegmental ventral, median este efecto dependiente de la dopamina, lo que sugiere una nueva vía para la mejora de la memoria.
Área de la Ciencia:
- La neurociencia
- Investigación de la memoria
- Neurobiología
Sus antecedentes:
- La retención de memoria de tipo episódico se ve reforzada por la novedad poco antes o después de la codificación en humanos y animales.
- Este efecto novedoso dependiente de la dopamina se atribuía previamente exclusivamente a las neuronas que expresan tirosina-hidroxilasa (TH+) en el área tegmental ventral.
Objetivo del estudio:
- Identificar las neuronas específicas que median la mejora de la memoria dependiente de la dopamina asociada con la novedad.
- Investigar el papel de las neuronas del locus coeruleus (LC) en la mejora de la memoria asociada a la novedad.
Principales métodos:
- Utilizó una tarea de memoria cotidiana en ratones.
- Se ha registrado la sensibilidad de activación neuronal a la novedad ambiental.
- Proyecciones comparadas de neuronas LC TH + y neuronas TH + del área tegmental ventral al hipocampo.
- Se utiliza la activación optogenética de las neuronas LC TH+.
- Inactivado el área tegmental ventral.
- Se ha administrado bloqueo de los receptores D1/ D5 del hipocampo y bloqueo de los adrenoceptores.
Principales resultados:
- La activación neuronal en el locus coeruleus (LC) es muy sensible a la novedad ambiental.
- Las neuronas LC TH + se proyectan más extensamente al hipocampo que las neuronas TH + del área tegmental ventral.
- La activación optogenética de las neuronas LC TH + replicó la mejora de la memoria inducida por la novedad.
- La inactivación del área tegmental ventral no afectó la mejora de la memoria asociada a la novedad.
- Los efectos de la fotoactivación de LC TH+ en la memoria y la potenciación sináptica fueron bloqueados por el bloqueo de los receptores D1/ D5 del hipocampo, pero no por el bloqueo de los adrenoceptores.
Conclusiones:
- Las neuronas TH + del locus coeruleus, no las neuronas TH + del área tegmental ventral, median la mejora de la memoria posterior a la codificación.
- Esta mejora es dependiente de la dopamina, actuando a través de los receptores D1/D5 del hipocampo.
- Las neuronas LC TH + pueden liberar dopamina en el hipocampo para facilitar la memoria.
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