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Truco o tratamiento para la tolerancia a las enfermedades: dé a su cerebro algo bueno para comer
1Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell
|September 10, 2016
Resumen
La enfermedad causa anorexia, alterando las necesidades metabólicas para el estrés celular. Esto impacta la tolerancia a la enfermedad de manera diferente en las infecciones bacterianas frente a las virales, optimizando las estrategias de defensa del huésped.
Área de la Ciencia:
- Inmunología
- Las vías metabólicas
- Interacciones huésped-patógeno
Sus antecedentes:
- Las estrategias de defensa del huésped durante la infección a menudo implican cambios en el comportamiento de alimentación.
- La repriorización de las motivaciones de alimentación tiene como objetivo optimizar las respuestas del huésped a los patógenos.
Objetivo del estudio:
- Investigar cómo la anorexia inducida por la enfermedad influye en los requisitos metabólicos para las adaptaciones al estrés celular.
- Determinar el impacto diferencial de la anorexia en la tolerancia a la enfermedad durante las infecciones bacterianas frente a las virales.
Principales métodos:
- Análisis de los cambios metabólicos asociados con la anorexia durante la infección.
- Evaluación comparativa de la tolerancia del huésped a los patógenos bacterianos y virales en condiciones de anorexia.
Principales resultados:
- La anorexia inducida por la enfermedad modela diferencialmente las necesidades metabólicas para las respuestas de estrés celular.
- La anorexia ejerce efectos opuestos sobre la tolerancia a la enfermedad dependiendo de si la infección es bacteriana o viral.
Conclusiones:
- Los cambios en el comportamiento alimentario durante la enfermedad tienen consecuencias metabólicas distintas.
- Comprender estos cambios metabólicos es crucial para desarrollar terapias dirigidas para mejorar la tolerancia de la enfermedad a diferentes tipos de infecciones.
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