Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Thermosensation01:43

Thermosensation

34.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
34.6K
Body Temperature01:25

Body Temperature

5.2K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
5.2K
Body Temperature01:07

Body Temperature

1.7K
Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C...
1.7K
Thermoregulation01:26

Thermoregulation

2.9K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
2.9K
What is Homeostasis?01:16

What is Homeostasis?

66.0K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
66.0K
Somatosensation01:33

Somatosensation

44.6K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
44.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

A genome-wide screen identifies that PLCG2 restrains lysosomal GCase activity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Age-related morphological changes in the <i>C57BL/6J</i> mouse calvaria: implications for stereotaxic neurosurgery.

bioRxiv : the preprint server for biology·2026
Same author

An orthogonal TRAP enables intersectional genetic access to activated neurons in the mouse brain.

bioRxiv : the preprint server for biology·2026
Same author

A genetic screen in enteroendocrine cells reveals mechanisms that control protein sensing and GLP-1 release.

bioRxiv : the preprint server for biology·2026
Same author

Need-selective gating of dopamine neuron cue responses by real and virtual hunger.

bioRxiv : the preprint server for biology·2026
Same author

Cellular coding of ingestion in the caudal brainstem.

bioRxiv : the preprint server for biology·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Mar 15, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

15.8K

Neuronas sensibles al calor que controlan la temperatura del cuerpo

Chan Lek Tan1, Elizabeth K Cooke1, David E Leib2

  • 1Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.

Cell
|September 13, 2016
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores han identificado en el cerebro neuronas específicas sensibles al calor que controlan la temperatura corporal. Estas neuronas, que coexpresan BDNF y PACAP, desencadenan respuestas de enfriamiento y comportamiento de búsqueda de frío cuando son activadas por el calor.

Más Videos Relacionados

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
11:08

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

Published on: June 3, 2016

7.7K
In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia
09:07

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia

Published on: February 10, 2023

3.7K

Videos de Experimentos Relacionados

Last Updated: Mar 15, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

15.8K
Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
11:08

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

Published on: June 3, 2016

7.7K
In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia
09:07

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia

Published on: February 10, 2023

3.7K

Área de la Ciencia:

  • La neurociencia
  • Fisiología
  • Biología molecular

Sus antecedentes:

  • La termorregulación es una función cerebral crítica para mantener la temperatura corporal estable.
  • Los circuitos neuronales y los tipos específicos de células responsables de convertir las señales de temperatura en respuestas homeostáticas no se comprenden completamente.

Objetivo del estudio:

  • Identificar y caracterizar las neuronas específicas en el cerebro responsables de detectar el calor y iniciar respuestas de pérdida de calor.
  • Para aclarar la identidad molecular y la conectividad funcional de estas neuronas sensibles al calor (WSNs).

Principales métodos:

  • Se utilizó la secuenciación de ARN imparcial y dependiente de la actividad para descubrir nuevas poblaciones neuronales.
  • Realizó grabaciones ópticas en ratones despiertos y con comportamiento para monitorear la actividad neuronal en respuesta a estímulos térmicos.
  • Optogenética empleada para la excitación dirigida de WSNs identificados y manipulaciones específicas de proyección.

Principales resultados:

  • Se identificó una población de neuronas sensibles al calor (WSN) en el hipotálamo preóptico definida por la coexpresión de BDNF y PACAP.
  • Se demostró que las WSN se activan selectivamente por el calor ambiental en ratones con comportamiento.
  • Se demostró que la activación optogenética de WSNs induce hipotermia rápida y comportamiento de búsqueda de frío a través de vías neuronales distintas.

Conclusiones:

  • Los WSN que coexpresan BDNF y PACAP son jugadores celulares clave en la termorregulación de los mamíferos.
  • Estas neuronas coordinan las respuestas autónomas (pérdida de calor) y conductuales (búsqueda de frío) al calor.
  • Proporciona acceso genético al circuito neuronal central que gobierna la regulación de la temperatura corporal.