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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
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Cuadros orgánicos covalentes porosos homoquirales 2D para catálisis asimétrica heterogénea
Xiuren Wang1, Xing Han1, Jie Zhang1
1School of Chemistry and Chemical Engineering and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University , Shanghai 200240, China.
Journal of the American Chemical Society
|September 14, 2016
Resumen
Los investigadores desarrollaron nuevos marcos orgánicos covalentes quirales (COF) para la catálisis. Estos nuevos materiales porosos catalizan eficientemente las reacciones asimétricas con alta enantioselectividad, ofreciendo soluciones reciclables y sintonizables.
Área de la Ciencia:
- Ciencias de los materiales
- Química orgánica
- Catálisis
Sus antecedentes:
- Los marcos orgánicos covalentes (COF) ofrecen propiedades sintonizables, pero la síntesis de COF quirales es un desafío.
- Los materiales porosos quirales son cruciales para la catálisis enantioselectiva.
Objetivo del estudio:
- Para construir COFs bidimensionales con funcionalidades quirales incrustadas.
- Desarrollar catalizadores heterogéneos eficientes y reciclables para la síntesis asimétrica.
Principales métodos:
- Reacciones de condensación de imina mediante el uso de tetraaldehídos derivados del enantiopuro TADDOL y 4,4'-diaminodifenilmetano.
- Caracterización mediante difracción de rayos X en polvo y modelado por computadora.
- Modificación post-sintética con TiOPr4 para la actividad catalítica.
Principales resultados:
- Se han sintetizado con éxito dos tipos de COF 2D con estructuras de red distintas (interpenetradas y no interpenetradas).
- Los COF modificados demostraron una alta eficiencia y reciclabilidad como catalizadores heterogéneos.
- Se obtiene una alta enantioselectividad en la adición asimétrica de dietilzinco a los aldehídos.
Conclusiones:
- Este trabajo presenta una estrategia viable para el diseño y la síntesis de COFs quirales.
- Los FOC quirales desarrollados muestran un gran potencial como catalizadores heterogéneos para transformaciones asimétricas.
- Amplía las posibilidades para crear nuevos materiales porosos funcionales.
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