Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Antibiotic Selection00:57

Antibiotic Selection

61.8K
Overview
61.8K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

7.1K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
7.1K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.8K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.8K
Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration01:23

Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration

70
Drug elimination from the body primarily occurs through metabolic and excretion pathways. Hepatic metabolism transforms lipophilic drugs into hydrophilic forms for excretion, typically via enzymatic processes classified as phase I (modification) and phase II (conjugation). Renal excretion eliminates drugs and metabolites through filtration and secretion in the kidneys. Impairment in liver or kidney function can hinder these processes, delaying drug clearance and extending the drug’s...
70
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

520
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
520
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

1.8K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.8K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.

Nature·2026
Same author

The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the European Committee on Antimicrobial Susceptibility Testing Subcommittee.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Ngt-1: A glycosyltransferase that confers resistance to three distinct antibiotic classes.

The Journal of biological chemistry·2026
Same author

A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation.

Disease models & mechanisms·2026
Same author

Directed evolution of the pathogenic mold <i>Aspergillus fumigatus</i> reveals novel genes contributing to triazole resistance.

Antimicrobial agents and chemotherapy·2026
Same author

An Acetyltransferase Conferring Self-Resistance of the Producer to Lasso Peptide Antibiotic Lariocidin.

ACS infectious diseases·2026

Video Experimental Relacionado

Updated: Mar 14, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.8K

El poder de los antibióticos más antiguos

Gerard D Wright1

  • 1Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.

Cell
|October 8, 2016
PubMed
Resumen

Avycaz, una combinación de ceftazidima y avibactam, combate las infecciones bacterianas. El avibactam protege a la ceftazidima de las enzimas bacterianas, superando la resistencia a los medicamentos.

Área de la Ciencia:

  • Microbiología
  • Farmacología
  • Enfermedades infecciosas

Sus antecedentes:

  • Las infecciones bacterianas representan una amenaza significativa para la salud mundial.
  • La resistencia a los antibióticos, particularmente debido a las enzimas β-lactamasas, es un desafío creciente.
  • La ceftazidima es un antibiótico de cefalosporina eficaz contra muchas bacterias Gram negativas.

Objetivo del estudio:

  • Describir el mecanismo de acción de Avycaz (ceftazidima-avibactam).
  • Explicar cómo el avibactam supera la resistencia mediada por la β-lactamasa.
  • Destacar el papel de las proteínas de unión a la penicilina (PBPs) en la eficacia de los antibióticos.

Principales métodos:

  • El estudio se centra en las interacciones bioquímicas entre los componentes de Avycaz y las bacterias diana.

Más Videos Relacionados

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
08:23

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes

Published on: March 2, 2020

13.7K
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.6K

Videos de Experimentos Relacionados

Last Updated: Mar 14, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.8K
Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
08:23

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes

Published on: March 2, 2020

13.7K
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.6K
  • Detalla la inhibición de las enzimas β-lactamasas por el avibactam.
  • Describe la unión de la ceftazidima a los PBPs esenciales para la síntesis de la pared celular bacteriana.

    • Principales resultados:

    • Avycaz combina la ceftazidima, dirigida a la síntesis de la pared celular bacteriana a través de PBPs, con el avibactam.
    • El avibactam actúa como inhibidor de la β-lactamasa, impidiendo la inactivación de la ceftazidima.
    • Esta combinación restaura la eficacia de la ceftazidima contra las bacterias productoras de β-lactamasas.

    Conclusiones:

    • Avycaz representa una nueva estrategia terapéutica contra las infecciones bacterianas resistentes.
    • La combinación neutraliza eficazmente los mecanismos de resistencia bacteriana mediados por las β-lactamasas.
    • Este enfoque mejora la utilidad de los antibióticos establecidos como la ceftazidima.