Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.9K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.9K
Limits to Natural Selection01:38

Limits to Natural Selection

35.7K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
35.7K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

2.6K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
2.6K
Convergent Evolution01:54

Convergent Evolution

34.1K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
34.1K
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

8.2K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
8.2K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.9K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.9K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease.

eLife·2026
Same author

Non-coding structural variants disrupt FOXG1 transcriptional regulation in early neurodevelopment.

Nature communications·2026
Same author

Cis-regulatory evolution shapes facial diversity in birds and mammals.

Science advances·2026
Same author

Enhancers that direct gene expression to central nervous system vascular endothelial cells in vivo.

Neuron·2026
Same author

Multi-season analysis reveals hundreds of drought-responsive genes in sorghum.

The Plant journal : for cell and molecular biology·2026
Same author

Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development.

bioRxiv : the preprint server for biology·2026

Video Experimental Relacionado

Updated: Mar 13, 2026

A Rapid In Vivo Bioassay for Developmentally Active Enhancers
00:08

A Rapid In Vivo Bioassay for Developmentally Active Enhancers

1.5K

Pérdida progresiva de la función en un potenciador de extremidades durante la evolución de las serpientes

Evgeny Z Kvon1, Olga K Kamneva2, Uirá S Melo1

  • 1MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Cell
|October 22, 2016
PubMed
Resumen

La evolución de las serpientes implicó cambios en un potenciador de extremidades que controlaba a Sonic Hedgehog. La restauración de un solo sitio de unión en este potenciador restauró completamente el desarrollo de las extremidades, revelando secuencias reguladoras.

Palabras clave:
CRISPR y Cas9El erizo sónico (Shh)ZRS (en inglés)Elemento cis-reguladormejoradorEl evo-devoEdición del genomadesarrollo de las extremidadesEvolución morfológicalas serpientes

Más Videos Relacionados

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

2.7K
Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

7.7K

Videos de Experimentos Relacionados

Last Updated: Mar 13, 2026

A Rapid In Vivo Bioassay for Developmentally Active Enhancers
00:08

A Rapid In Vivo Bioassay for Developmentally Active Enhancers

1.5K
Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

2.7K
Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

7.7K

Área de la Ciencia:

  • Biología del desarrollo evolutivo
  • Genómica comparada
  • Evolución molecular

Sus antecedentes:

  • La evolución de la forma del cuerpo está vinculada a cambios en la secuencia reguladora.
  • Los mecanismos moleculares detrás de las principales transiciones morfológicas de los vertebrados no se comprenden bien.

Objetivo del estudio:

  • Investigar los eventos moleculares que impulsan las principales transiciones morfológicas en los vertebrados.
  • Identificar cambios específicos en la secuencia de los elementos reglamentarios asociados con la evolución del plan de carrocería.

Principales métodos:

  • Cambios de secuencia específicos de serpiente identificados en un potenciador de extremidades de Sonic hedgehog (Shh) conservado.
  • Se utilizaron ensayos de reporte de ratón transgénico para probar la actividad del potenciador in vivo.
  • Realizó experimentos de sustitución genómica en ratones utilizando potenciadores ortólogos de diferentes especies.
  • Recuperado sintéticamente un sitio de unión al factor de transcripción perdido.

Principales resultados:

  • El patrón de actividad del potenciador de extremidades se conserva en los vertebrados como los peces, pero se altera en las serpientes.
  • El reemplazo del potenciador de ratón por ortólogos humanos o de peces dio lugar a un desarrollo normal de las extremidades.
  • Los ortólogos de la serpiente del potenciador causaron una reducción severa de las extremidades en ratones.
  • La restauración de un solo sitio de unión del factor de transcripción perdido rescató la función del potenciador en las serpientes.

Conclusiones:

  • Los cambios en una secuencia reguladora específica están asociados con la transición del plan corporal principal a formas similares a las de la serpiente.
  • Los potenciadores juegan un papel crítico en la evolución morfológica.
  • Identificó un mecanismo regulador clave que subyace a la pérdida de extremidades en las serpientes.