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El Consorcio Internacional del Epigenoma Humano: Un proyecto para la colaboración científica y el descubrimiento
Hendrik G Stunnenberg1, 2, Martin Hirst3
1Department of Molecular Biology, Faculties of Science and Medicine, Radboud University, Nijmegen, 6525AG, the Netherlands.
Cell
|November 19, 2016
Resumen
El Consorcio Internacional del Epigenoma Humano (IHEC) creó un catálogo de epigenomas de células humanas. Estos conjuntos de datos epigenómicos ofrecen información sobre el control epigenético relevante para la salud y las enfermedades humanas.
Área de la Ciencia:
- La genómica
- La epigenética
- Biología celular
Sus antecedentes:
- El Consorcio Internacional del Epigenoma Humano (IHEC) tiene como objetivo generar datos epigenómicos integrales.
- Comprender la regulación epigenética es crucial para la salud humana y la investigación de enfermedades.
Objetivo del estudio:
- Presentar los logros coordinados de los equipos del IHEC en la generación e interpretación de conjuntos de datos epigenómicos.
- Para obtener información sobre el control epigenético de los estados celulares.
Principales métodos:
- Generación de epigenomas de referencia de alta resolución para los principales tipos de células humanas primarias.
- Recopilación e interpretación de conjuntos de datos epigenómicos completos.
Principales resultados:
- Se ha generado un catálogo de epigenomas de referencia.
- Los esfuerzos coordinados han producido importantes conocimientos sobre la regulación epigenética.
Conclusiones:
- El IHEC ha compilado con éxito extensos datos epigenómicos.
- Estos hallazgos contribuyen a comprender los estados celulares y su relevancia para la salud y las enfermedades humanas.
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