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Programas de ritmo diurno de la microbiota Oscilaciones del transcriptoma del huésped

Christoph A Thaiss1, Maayan Levy1, Tal Korem2

  • 1Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Cell
|December 3, 2016
PubMed
Resumen
Este resumen es generado por máquina.

La microbiota intestinal

Palabras clave:
biogeografíacronofarmacologíareloj circadianoritmo diurnoel metabolomael metagenomael microbiomaEl transcriptoma

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Área de la Ciencia:

  • Microbiología
  • Cronología
  • Metabolomía

Sus antecedentes:

  • La microbiota intestinal exhibe ritmos diarios que influyen en la salud metabólica.
  • Los mecanismos que vinculan los ritmos microbianos a la actividad circadiana del huésped no están claros.

Objetivo del estudio:

  • Investigar cómo los ritmos microbianos intestinales influyen en la actividad circadiana del huésped.
  • Aclarar el papel de la biogeografía microbiana y el metaboloma en la regulación del ritmo del huésped.

Principales métodos:

  • Técnicas multiómicas integradas (genómica, transcriptómica y metabolómica) y técnicas de imágenes.
  • Análisis de los cambios diurnos en la localización microbiana y los perfiles de los metabolitos.
  • Evaluación de las oscilaciones transcripcionales, epigenéticas y metabólicas del huésped.

Principales resultados:

  • La microbiota intestinal muestra localización oscilante y patrones de metaboloma.
  • La actividad microbiana diurna dicta la exposición epitelial del huésped a las bacterias y los metabolitos.
  • Los ritmos microbianos impulsan las oscilaciones circadianas, epigenéticas y metabólicas del huésped.
  • La ritmicidad perturbada del microbioma conduce a oscilaciones en todo el genoma en los tejidos del huésped, afectando la fisiología y la enfermedad.

Conclusiones:

  • La biogeografía de la microbiota intestinal rítmica y el metaboloma son cruciales para la organización temporal de los programas circadianos del huésped.
  • La ritmicidad microbiana regula los resultados funcionales de los procesos transcripcionales y epigenéticos del huésped.
  • La alteración del ritmo microbiano tiene profundos efectos sistémicos en la fisiología del huésped y la susceptibilidad a las enfermedades.