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Protocol for Acute and Chronic Ecotoxicity Testing of the Turquoise Killifish Nothobranchius furzeri
Published on: April 24, 2018
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El paisaje genómico de la rápida y repetida adaptación evolutiva a la contaminación tóxica en los peces silvestres
Noah M Reid1, Dina A Proestou2, Bryan W Clark3
1Department of Environmental Toxicology, University of California, Davis, CA 95616, USA.
Science (New York, N.Y.)
|December 13, 2016
Resumen
El killifish atlántico se adaptó rápidamente a la contaminación urbana al modificar la vía del receptor de hidrocarburos de arilo. Diferentes cambios moleculares en las poblaciones muestran flexibilidad evolutiva para adaptarse a entornos tóxicos.
Área de la Ciencia:
- Toxicología ambiental
- Biología evolutiva
- La genómica
Sus antecedentes:
- Los estuarios urbanos presentan desafíos tóxicos extremos.
- El killifish del Atlántico muestra una notable adaptación a la contaminación.
Objetivo del estudio:
- Investigar la base genética de la rápida adaptación a la contaminación en el killifish del Atlántico.
- Identificar objetivos moleculares compartidos y distintos de la selección.
Principales métodos:
- Secuenciación completa del genoma de 384 killifish del Atlántico.
- Transcriptómica comparativa de las poblaciones sensibles y tolerantes.
- Análisis de la vía de señalización del receptor de hidrocarburos de arilo.
Principales resultados:
- La vía del receptor de hidrocarburos de arilo es un objetivo común de selección en todas las poblaciones.
- Las distintas variantes moleculares contribuyen a la adaptación dentro de las poblaciones.
- La selección actúa sobre otros genes relacionados con la toxicidad, lo que indica adaptaciones complejas.
Conclusiones:
- La rápida adaptación a mezclas tóxicas complejas es facilitada por la restricción evolutiva y la variación genética permanente.
- La alta diversidad de nucleótidos en el killifish apoya la rápida evolución adaptativa.
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