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Updated: Mar 8, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Published on: July 17, 2020

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El ligando Sas y su receptor PTP10D impulsan la competencia celular supresora del tumor

Masatoshi Yamamoto1, Shizue Ohsawa1, Kei Kunimasa1

  • 1Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Nature
|January 17, 2017
PubMed
Resumen

Las células epiteliales normales eliminan a las vecinas oncogénicas mediante la competencia celular, mediada por el sistema Sas-PTP10D. Esta interacción restringe la señalización de EGFR, promoviendo la señalización de JNK para la supresión tumoral.

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