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Morphogenesis02:19

Morphogenesis

30.6K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
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Forced Transdifferentiation01:28

Forced Transdifferentiation

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Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
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Gastrulation01:56

Gastrulation

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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Cellular Differentiation00:57

Cellular Differentiation

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How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Video Experimental Relacionado

Updated: Mar 8, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
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Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

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Desde el morfogén a la morfogénesis y viceversa

Darren Gilmour1, Martina Rembold2,3, Maria Leptin1,2

  • 1European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Nature
|January 20, 2017
PubMed
Resumen
Este resumen es generado por máquina.

Los científicos están descubriendo cómo los genomas dictan la forma del organismo al vincular el control genético del destino celular con la maquinaria celular. Esta investigación cierra la brecha entre el genotipo y el fenotipo, avanzando en la comprensión del ensamblaje robusto de órganos y la ingeniería de tejidos.

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Área de la Ciencia:

  • Biología del desarrollo
  • La genómica
  • La biofísica

Sus antecedentes:

  • Comprender el papel del genoma en la forma del organismo es un objetivo clave en las ciencias de la vida.
  • Para cerrar la brecha entre el genotipo y el fenotipo se requiere vincular el control genético del destino celular con los mecanismos generadores de la forma celular.

Objetivo del estudio:

  • Identificar los vínculos mecanicistas entre los genes que controlan el destino celular y la maquinaria celular que genera la forma.
  • Aclarar la lógica y los mecanismos que integran diferentes niveles de control de la forma.
  • Proporcionar un marco para la ingeniería de tejidos basado en una comprensión integral de la morfogénesis.

Principales métodos:

  • Investigando el control genético de las decisiones del destino celular.
  • Analizando las máquinas celulares responsables de generar la forma biológica.
  • Estudiar los mecanismos de intercambio y retroalimentación en el ensamblaje de órganos.

Principales resultados:

  • Se están identificando vínculos mecánicos entre los genes y la generación de formas celulares.
  • La lógica de integración y los mecanismos para el control de la forma están surgiendo.
  • Los mecanismos de intercambio y retroalimentación contribuyen a la robustez del ensamblaje de órganos.

Conclusiones:

  • Está surgiendo una comprensión del "círculo completo" de la morfogénesis.
  • Esta comprensión resuelve un rompecabezas clave en la biología.
  • Los hallazgos proporcionan un marco para futuros enfoques de ingeniería de tejidos.