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La superposición de huellas de memoria es indispensable para vincular, pero no recordar, los recuerdos individuales.
Jun Yokose1,2, Reiko Okubo-Suzuki1,2, Masanori Nomoto1,2
1Department of Biochemistry, Faculty of Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Science (New York, N.Y.)
|January 28, 2017
Resumen
Un pequeño grupo de neuronas compartidas en la amígdala enlaza los recuerdos, permitiendo que una señal de memoria desencadene otra. El silenciamiento de estas neuronas interrumpe la asociación de la memoria pero no el recuerdo individual.
Área de la Ciencia:
- La neurociencia
- Investigación de la memoria
- Ciencias del comportamiento
Sus antecedentes:
- Las memorias están integradas en redes, no aisladas.
- Los mecanismos de asociación de la memoria no se comprenden completamente.
Objetivo del estudio:
- Investigar las bases neuronales de la asociación de la memoria.
- Identificar los conjuntos neuronales que median enlaces entre los recuerdos.
Principales métodos:
- Aversión al gusto condicionada (CTA) y acondicionamiento del miedo por inducción auditiva (AFC) en ratones.
- El conjunto neuronal examinado se superpone en la amígdala basolateral.
- Silenció conjuntos neuronales superpuestos para evaluar la recuperación de la memoria.
Principales resultados:
- La presentación del estímulo condicionado CTA desencadenó la respuesta condicionada AFC después de la coactivación de la memoria.
- Se observó un aumento de los conjuntos neuronales superpuestos en la amígdala basolateral.
- El silenciamiento de conjuntos superpuestos suprime el congelamiento inducido por la recuperación de CTA, sin afectar el recuerdo individual.
Conclusiones:
- Una pequeña población de neuronas compartidas media el vínculo entre los recuerdos.
- Estas neuronas compartidas son cruciales para la asociación de la memoria pero no para recordar recuerdos individuales.
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