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Las trayectorias de la hormona antimülleriana están asociadas con enfermedades cardiovasculares en las mujeres:

Annelien C de Kat¹, W Monique Verschuren², Marinus J C Eijkemans²

¹From Department of Reproductive Medicine and Gynecology (A.C.d.K., F.J.M.B.), Julius Center for Health Sciences and Primary Care (A.C.d.K., W.M.V., M.J.C.E., Y.T.V.D.S.), University Medical Center Utrecht, The Netherlands; and National Institute for Public Health and the Environment, Bilthoven, The Netherlands (W.M.V.). y.t.vanderschouw@umcutrecht.nl.

|February 4, 2017

Resumen

La disminución de los niveles de hormona anti-Mülleriana (AMH) en las mujeres está relacionada con un mayor riesgo de enfermedad cardiovascular (ECV). Esto sugiere que la AMH puede desempeñar un papel en los efectos cardiovasculares de la menopausia temprana.

Área de la Ciencia:

Endocrinología
Medicina cardiovascular
Salud Reproductiva

Sus antecedentes:

La menopausia temprana está asociada con un mayor riesgo de enfermedad cardiovascular (ECV).
Los mecanismos que vinculan la menopausia temprana a las enfermedades cardiovasculares aún no están claros.
La hormona antimülleriana (AMH), un marcador de la reserva ovárica, puede tener funciones no reproductivas.

Objetivo del estudio:

Investigar la asociación entre las trayectorias longitudinales de disminución de la hormona antimülleriana (HMA) y el riesgo de aparición de enfermedades cardiovasculares (ECV).
Explorar el papel potencial de la AMH en la fisiopatología de las ECV en las mujeres.

Principales métodos:

Estudio de cohorte de Doetinchem basado en la población con 3108 participantes femeninas (20-60 años al inicio del estudio).
Seguimiento de 20 años con 5 visitas consecutivas y medición de AMH en 8507 muestras de plasma.
Modelado conjunto utilizado para evaluar la asociación de las trayectorias de HMA con ECV, ajustándose a múltiples factores de riesgo.

Principales resultados:

Los niveles más bajos de AMH se asociaron con un aumento del 21% en el riesgo de ECV y un aumento del 26% en el riesgo de enfermedad coronaria.
Una disminución más rápida de los niveles de AMH (por ng/ ml/ año) se relacionó con un riesgo significativamente mayor de ECV (HR 1,46) y enfermedad coronaria (HR 1,56).
No se encontró una asociación significativa entre la AMH y el riesgo de accidente cerebrovascular.

Conclusiones:

Las trayectorias longitudinales de AMH se asocian de forma independiente con el riesgo de ECV en las mujeres.
La disminución de los niveles de AMH puede contribuir al aumento del riesgo cardiovascular observado con la menopausia temprana.
Se necesita más investigación para confirmar estos hallazgos y aclarar los mecanismos subyacentes.

Palabras clave:

Enfermedad coronaria la menopausia las mujeres

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