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Los principios de la ingeniería de células inmunes para tratar el cáncer

Wendell A Lim¹, Carl H June²

¹Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, UCSF Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA.

|February 11, 2017

Resumen

Las células inmunes diseñadas, conocidas como células T receptoras de antígenos quiméricos (CAR), son prometedoras como terapias contra el cáncer. Las herramientas de biología sintética están avanzando las terapias de células T CAR para un tratamiento tumoral más amplio y una mayor seguridad.

Área de la Ciencia:

Inmunología
Biotecnología
En el campo de la oncología

Sus antecedentes:

Las células T del receptor del antígeno quimérico (CAR) representan un avance significativo en la inmunoterapia contra el cáncer.
Las aplicaciones clínicas han puesto de relieve los desafíos en seguridad, confiabilidad y amplia aplicabilidad del tumor.

Objetivo del estudio:

Explorar el potencial de la biología sintética en el avance de las terapias con células T CAR.
Para discutir el diseño de la próxima generación de terapias de células T inteligentes.

Principales métodos:

Revisión de la experiencia clínica con el tratamiento con células T CAR.
Análisis de las herramientas emergentes de biología sintética para la ingeniería celular.

Principales resultados:

Las células T CAR son una nueva y poderosa clase de terapias contra el cáncer.
La biología sintética ofrece herramientas ampliadas para programar las células inmunes.

Conclusiones:

Los enfoques de biología sintética pueden abordar los desafíos actuales en la terapia de células T CAR.
Estas herramientas pueden permitir el desarrollo de terapias de precisión de células T sofisticadas de próxima generación para diversos tipos de cáncer.

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