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Análisis de seguridad combinado de Evolocumab en más de 6000 pacientes de estudios de extensión doble ciego y abierto

Peter P Toth1, Olivier Descamps2, Jacques Genest2

  • 1From CGH Medical Center, Sterling, IL, and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.); Lipid Clinic, Centres Hospitaliers Jolimont, Haine-Saint-Paul, Belgium (O.D.); The McGill University Health Centre, Montreal, Canada (J.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK (N.S.); Medical Research Council Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, UK (D.P.); and Amgen Inc, Thousand Oaks, CA (R.D., C.D., Y.W., M.G., M.U., R.S., S.M.W.). peter.toth@cghmc.com.

Circulation
|March 3, 2017
PubMed
Resumen

Evolocumab, un inhibidor de PCSK9, demostró una seguridad y tolerabilidad similares en comparación con los controles en ensayos clínicos. Este análisis de más de 6000 pacientes apoya su perfil de beneficio-riesgo favorable para el control del colesterol.

Palabras clave:
anticuerpos monoclonalescolesterol y LDLeventos adversos a largo plazoMialgia en el cuerpoLa proproteína convertasa 9

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