Modulación específica de la inhibición dendrítica neocortical durante la vigilia activa
William Muñoz1, Robin Tremblay1, Daniel Levenstein1,2
1Neuroscience Institute and Department of Neuroscience and Physiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Science (New York, N.Y.)
|March 4, 2017
Resumen
Las interneuronas que expresan somatostatina en el cerebro muestran cambios de actividad opuestos durante la vigilia, revelando una inhibición específica de la capa. Esto pone de relieve cómo la actividad colinérgica y VIP de las interneuronas controla la señalización dendrítica en el neocórtex.
Área de la Ciencia:
- La neurociencia
- La neurociencia celular
- Neurociencia de los sistemas
Sus antecedentes:
- El ácido γ-aminobutírico (GABA) regula la integración sináptica en las células piramidal.
- La dinámica espacio-temporal de las entradas GABAérgicas durante el comportamiento no se entiende bien.
Objetivo del estudio:
- Investigar la modulación específica por capa de la actividad de las interneuronas que expresan somatostatina (Sst) en ratones con comportamiento.
- Comprender el papel de las interneuronas de péptidos intestinales vasoactivos (Vip) y la modulación colinérgica en la actividad de las Sst interneuronas.
Principales métodos:
- Se utilizó etiquetado óptico y electrofisiología para registrar y etiquetar las Sst interneuronas.
- Los experimentos se llevaron a cabo en ratones con comportamiento.
Principales resultados:
- Los subtipos de interneuronas en diferentes capas corticales mostraron cambios de actividad opuestos durante las transiciones a la vigilia activa.
- La actividad de las interneuronas Sst fue modulada por la inhibición mediada por Vip y la entrada colinérgica.
- Distintos subtipos de Sst interneuron inervaron los dominios laminares complementarios.
Conclusiones:
- La inhibición mediada por interneuron es modulada por el estado conductual de una manera específica de la capa.
- Esto proporciona información sobre la regulación compartimentada de la señalización dendrítica en el neocórtex de los mamíferos.
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