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Engramas y circuitos cruciales para la consolidación de sistemas de una memoria
Takashi Kitamura1, Sachie K Ogawa1, Dheeraj S Roy1
1RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Departments of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science (New York, N.Y.)
|April 8, 2017
Resumen
Una nueva investigación revela cómo los engramas de memoria se reorganizan durante la consolidación de los sistemas. Inicialmente formado en el hipocampo, las huellas de memoria se desplazan a redes neocorticales, con los engramas de la corteza prefrontal que se vuelven cruciales para el almacenamiento de la memoria del miedo a largo plazo.
Área de la Ciencia:
- La neurociencia
- Consolidación de la memoria
- Neurociencia de los sistemas
Sus antecedentes:
- La formación de la memoria episódica se basa en la plasticidad sináptica del hipocampo, seguida de la consolidación neocortical.
- Los engramas y circuitos específicos involucrados en la consolidación de la memoria neocortical siguen siendo en gran medida desconocidos.
Objetivo del estudio:
- Para identificar los engramas y circuitos que apoyan la consolidación de la memoria neocortical.
- Para aclarar los cambios dinámicos en los engramas de memoria durante la consolidación de sistemas.
Principales métodos:
- Investigó las células de engramas de memoria prefrontal neocortical críticas para la memoria de miedo contextual remota.
- Las entradas examinadas de la red de corteza hipocampo-entorrinal y la amígdala basolateral durante el aprendizaje.
- Rastreó la maduración funcional y la persistencia de las células de engramas a lo largo del tiempo.
Principales resultados:
- Las células de engramas prefrontales neocorticales se generaron rápidamente durante el aprendizaje inicial a través de entradas de la amígdala hipocampo-entorrinal y basolateral.
- Las células del engrama prefrontal maduraron funcionalmente con el tiempo con el apoyo del hipocampo.
- Las células engramáticas del hipocampo se silenciaron gradualmente, mientras que las células engramáticas basolaterales de la amígdala se mantuvieron y fueron necesarias para la memoria del miedo.
Conclusiones:
- Proporciona nuevos conocimientos sobre la reorganización funcional de los engramas y circuitos durante la consolidación de los sistemas de memoria.
- Destaca la interacción dinámica entre los circuitos del hipocampo, el prefrontal y la amígdala en el almacenamiento de memoria a largo plazo.
- Identifica las células del engrama prefrontal como componentes clave de la consolidación remota de la memoria del miedo en el neocórtex.
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