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Síntesis total asimétrica del acetato de lancifodilactona G

Dong-Dong Liu¹, Tian-Wen Sun¹, Kuang-Yu Wang¹

¹Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University , Beijing 100871, China.

Journal of the American Chemical Society

|April 11, 2017

Resumen

Se logró la primera síntesis asimétrica total de acetato de lancifodilactona G. Esta compleja molécula fue sintetizada en 28 pasos a partir de un material de partida fácilmente disponible.

Área de la Ciencia:

Química orgánica
Química sintética
Síntesis de productos naturales

Sus antecedentes:

El acetato de lancifodilactona G es un producto natural estructuralmente complejo y altamente oxigenado.
La síntesis de tales moléculas intrincadas presenta desafíos significativos en la química orgánica.

Objetivo del estudio:

Para lograr la primera síntesis asimétrica total de acetato de lancifodilactona G.
Desarrollar una ruta sintética eficiente a partir de un material de partida simple.

Principales métodos:

La síntesis empleó una secuencia de 28 pasos.
El material de partida fue el producto químico commodity 2- ((triisopropylsiloxy) -1,3-butadieno.

Principales resultados:

Se logró la primera síntesis total asimétrica exitosa de acetato de lancifodilactona G.
La síntesis demostró la viabilidad de construir la compleja arquitectura molecular.

Conclusiones:

El estudio proporciona una vía viable para la síntesis del acetato de lancifodilactona G.
Este logro abre caminos para una mayor exploración de productos naturales relacionados.

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