Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

Design Consideration01:22

Design Consideration

681
Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
681
Plastic Behavior01:21

Plastic Behavior

819
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
819
Fatigue01:21

Fatigue

1.1K
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
1.1K
Bulk Modulus01:21

Bulk Modulus

1.0K
The bulk modulus is a scientific term used to describe a material's resistance to uniform compression. It is the proportionality constant that links a change in pressure to the resulting relative volume change.
1.0K
Toughness and Hardness of Aggregate01:22

Toughness and Hardness of Aggregate

1.1K
Toughness and hardness are critical properties of aggregate materials used in concrete, particularly on pavement surfaces and industrial flooring subjected to heavy loads. Toughness is defined as the aggregate's resistance to failure by impact and is measured by the aggregate impact value (AIV). For this, the aggregate impact value test is performed, wherein the impact is delivered by a standard hammer, which falls freely under its own weight onto the aggregates. The aggregates fragment in...
1.1K
Optimization Problems01:26

Optimization Problems

220
Optimization problems often involve identifying maximum or minimum values under specific constraints. A well-known example is determining the longest horizontal pipe that can be moved around a right-angled corner, where a 3-meter-wide hallway meets a 2-meter-wide hallway. This scenario, common in architectural design and industrial transport, can be understood conceptually through geometric and trigonometric reasoning.To visualize the problem, consider the pipe as a straight line that touches...
220

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Expert recommendations for the management of fecal incontinence in systemic sclerosis: A report from the World Scleroderma Foundation (WSF) Gastrointestinal "Ad hoc committee".

Journal of scleroderma and related disorders·2026
Same author

Expert recommendations for the management of refractory gastroesophageal reflux disease in systemic sclerosis: A report from the World Scleroderma Foundation (WSF) Gastrointestinal "Ad hoc committee".

Journal of scleroderma and related disorders·2026
Same author

Real-World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity-Matched Study from the EUSTAR Cohort.

Arthritis care & research·2026
Same author

Influence of comorbidities and patient demographics on Raynaud's symptom characteristics: implications for diagnosis and management.

Journal of scleroderma and related disorders·2026
Same author

Measuring disease activity in juvenile systemic sclerosis: a multidisciplinary consensus from the Hamburg 2024 symposium.

Expert review of clinical immunology·2026
Same author

Pulmonary arterial hypertension susceptibility and mortality among patients with systemic sclerosis with the DNASE1L3 rs35677470 (Arg206Cys) variant.

Annals of the rheumatic diseases·2026
Same journal

Safety and efficacy of mRNA vaccines: a mechanistic and public health perspective.

Lancet (London, England)·2026
Same journal

The US Ebola response and the future of global health leadership.

Lancet (London, England)·2026
Same journal

Daniel Mason: a tale of change.

Lancet (London, England)·2026
Same journal

The 2026 Wakley-Wu Lien Teh Prize Essay: why medicine, and why stay?

Lancet (London, England)·2026
Same journal

Indonesia's health reform: from pandemic mandate to the six pillars of transformation.

Lancet (London, England)·2026
Same journal

LGBTQ+ Russians increasingly avoiding doctors.

Lancet (London, England)·2026
Ver todos los artículos relacionados
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: May 7, 2026

Quantitative Hardness Measurement by Instrumented AFM-indentation
08:21

Quantitative Hardness Measurement by Instrumented AFM-indentation

Published on: November 22, 2016

9.3K

Esclerosis sistémica

Christopher P Denton1, Dinesh Khanna2

  • 1UCL Division of Medicine, University College London, London, UK; UCL Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, London, UK.

Lancet (London, England)
|April 18, 2017
PubMed
Resumen
Este resumen es generado por máquina.

La esclerosis sistémica (esclerodermia) es una enfermedad autoinmune grave que causa fibrosis. Los avances mejoran el manejo y el tratamiento de las complicaciones, pero los síntomas no letales siguen siendo un desafío importante.

Más Videos Relacionados

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
06:59

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

7.5K
Determining the Mechanical Strength of Ultra-Fine-Grained Metals
05:04

Determining the Mechanical Strength of Ultra-Fine-Grained Metals

Published on: November 22, 2021

1.7K

Videos de Experimentos Relacionados

Last Updated: May 7, 2026

Quantitative Hardness Measurement by Instrumented AFM-indentation
08:21

Quantitative Hardness Measurement by Instrumented AFM-indentation

Published on: November 22, 2016

9.3K
Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
06:59

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

7.5K
Determining the Mechanical Strength of Ultra-Fine-Grained Metals
05:04

Determining the Mechanical Strength of Ultra-Fine-Grained Metals

Published on: November 22, 2021

1.7K

Área de la Ciencia:

  • Reumatología
  • Inmunología
  • Investigación de la fibrosis

Sus antecedentes:

  • La esclerosis sistémica (esclerodermia) es una enfermedad reumática mediada por el sistema inmunológico caracterizada por fibrosis y vasculopatía.
  • Presenta una morbilidad y mortalidad significativas, afectando la piel y los órganos internos.
  • Los avances recientes han mejorado la comprensión, la clasificación y las estrategias de gestión.

Objetivo del estudio:

  • Revisar las características clínicas de la esclerosis sistémica.
  • Describir las mejores prácticas para el tratamiento de la enfermedad.
  • Identificar las futuras áreas de investigación y desarrollo.

Principales métodos:

  • Revisión de la literatura sobre las características clínicas y las estrategias de tratamiento.
  • Síntesis de la evidencia actual para los enfoques de tratamiento.
  • Análisis de la carga de enfermedades y desafíos futuros.

Principales resultados:

  • La mejora de la clasificación y la evaluación sistemática mejoran la gestión de la enfermedad.
  • Los tratamientos emergentes, incluida la inmunosupresión, muestran eficacia para la fibrosis cutánea y pulmonar.
  • Las complicaciones específicas como la crisis renal y la hipertensión pulmonar ahora son tratables.

Conclusiones:

  • Si bien el manejo y el tratamiento de complicaciones específicas han avanzado, la carga de complicaciones no letales de la esclerosis sistémica requiere más atención.
  • La gestión de las mejores prácticas implica una evaluación sistemática y terapias específicas.
  • La investigación futura debe centrarse en abordar la carga sustancial de las manifestaciones no letales.