Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.9K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.9K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.4K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.4K
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.4K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.4K
Ion Channels01:19

Ion Channels

92.1K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
92.1K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

14.7K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
14.7K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

11.9K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
11.9K
Esta página ha sido traducida por una máquina. Otras páginas pueden seguir apareciendo en inglés.View in English
  1. Home
  3. Áreas de investigación
  5. Ciencias De La Salud
  7. Epidemiología
  9. Epidemiología No Clasificada En Otra Parte
  11. Estructura De Cryo-em Del Canal Abierto Relacionado Con El Éter Humano Herg
  1. Home
  3. Áreas de investigación
  5. Ciencias De La Salud
  7. Epidemiología
  9. Epidemiología No Clasificada En Otra Parte
  11. Estructura De Cryo-em Del Canal Abierto Relacionado Con El Éter Humano Herg

Video Experimental Relacionado

Recapitulation of an Ion Channel IV Curve Using Frequency Components
10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

13.9K

Estructura de cryo-EM del canal abierto relacionado con el éter humano hERG

Weiwei Wang1, Roderick MacKinnon1

  • 1Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.

Cell
|April 22, 2017

Ver abstracta en PubMed

Resumen
Este resumen es generado por máquina.

La estructura del canal de potasio relacionado con el ether-to-go-go (hERG) humano revela su estado despolarizado y abierto. Esta estructura explica el hERG

Palabras clave:
El canal K ((+)Crio-EMIntervallo QT largo inducido por drogashERG

Más Videos Relacionados

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
15:28

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells

Published on: October 1, 2010

18.0K
Reconstitution of a Kv Channel into Lipid Membranes for Structural and Functional Studies
10:22

Reconstitution of a Kv Channel into Lipid Membranes for Structural and Functional Studies

Published on: July 13, 2013

20.1K

Videos de Experimentos Relacionados

Recapitulation of an Ion Channel IV Curve Using Frequency Components
10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

13.9K
Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
15:28

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells

Published on: October 1, 2010

18.0K
Reconstitution of a Kv Channel into Lipid Membranes for Structural and Functional Studies
10:22

Reconstitution of a Kv Channel into Lipid Membranes for Structural and Functional Studies

Published on: July 13, 2013

20.1K

Área de la Ciencia:

  • Biología molecular
  • Cardiología
  • Biología estructural

Sus antecedentes:

  • El canal de potasio relacionado con el éter en movimiento humano (hERG, Kv11.1) es crucial para la repolarización del potencial de acción cardíaca.
  • La disfunción de hERG está relacionada con el síndrome del intervalo QT largo y la torsade de pointes, una arritmia potencialmente fatal.

Objetivo del estudio:

  • Para determinar la estructura molecular del canal hERG.
  • Aclarar la base estructural de la función del canal hERG y la sensibilidad a los fármacos.

Principales métodos:

  • Se empleó microscopía criolectrónica para resolver la estructura hERG a una resolución de 3,8 Å.

Principales resultados:

  • La estructura determinada muestra hERG en una conformación despolarizada con un poro abierto.
Bloqueo hERG
desactivación
La estructura
Puertas dependientes de la tensión
  • Una cavidad central única con bolsillos hidrofóbicos puede explicar la sensibilidad a los medicamentos de hERG.
  • Una característica específica del filtro de selectividad puede estar relacionada con su rápida inactivación.

    • Conclusiones:

    • La estructura de alta resolución proporciona una visión sin precedentes de la entrada y la función del canal hERG.
    • Comprender la estructura de hERG es vital para desarrollar medicamentos más seguros y controlar las arritmias cardíacas.