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Mantenimiento de la actividad persistente en un bucle talamocortical frontal
Zengcai V Guo1, Hidehiko K Inagaki1, Kayvon Daie1
1Janelia Research Campus, HHMI, Ashburn, Virginia 20147, USA.
Nature
|May 4, 2017
Resumen
El tálamo y la corteza motora lateral anterior (ALM) exhiben una actividad neuronal persistente coordinada crucial para las acciones de guía. La interrupción de este circuito causa negligencia, destacando su papel en la preparación del motor.
Área de la Ciencia:
- La neurociencia
- Control del motor
- Los circuitos neuronales
Sus antecedentes:
- La actividad neuronal persistente es esencial para vincular eventos pasados y futuros.
- Si bien los circuitos locales están implicados, los circuitos de largo alcance también pueden contribuir a la actividad persistente.
- Las neuronas en la corteza motora lateral anterior (ALM) muestran una actividad selectiva persistente que guía las acciones futuras.
Objetivo del estudio:
- Investigar el papel de los circuitos tálamicos en la actividad neuronal persistente relacionada con la preparación motora.
- Para determinar la conectividad funcional entre el ALM y el tálamo durante una tarea de respuesta retardada.
Principales métodos:
- Grabaciones simultáneas de picos del ALM y el tálamo en ratones durante una tarea de discriminación táctil con respuesta direccional retrasada.
- Fotoinhibición unilateral de la actividad neuronal en el ALM y el tálamo.
Principales resultados:
- Las neuronas tálamicas mostraron una actividad de retraso persistente selectiva que predice la dirección del movimiento, reflejando la actividad de las neuronas ALM.
- La fotoinhibición unilateral de la actividad de retraso en el ALM o en el tálamo dio lugar a la negligencia contralesional.
- La fotoinhibición del tálamo condujo a una disminución rápida y significativa de la actividad de ALM, y viceversa.
Conclusiones:
- El tálamo actúa como un centro de circuito crítico en la preparación motora.
- La actividad neuronal persistente depende de la excitación recíproca entre múltiples áreas del cerebro, incluido el ALM y el tálamo.
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