Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Pinocytosis00:38

Pinocytosis

3.8K
Cells use energy-requiring bulk transport mechanisms to transfer large particles or large numbers of small particles into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
Pinocytosis ("cellular drinking") is one of three main types of...
3.8K
Pinocytosis00:43

Pinocytosis

68.5K
Cells use energy-requiring bulk transport mechanisms to transfer large particles, or large amounts of small particles, into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
68.5K
Phagocytosis00:41

Phagocytosis

7.0K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
7.0K
Phagocytosis00:41

Phagocytosis

89.1K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
89.1K
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

3.6K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
3.6K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

8.3K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.3K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Beyond transport: Lysosomal solute carriers as orchestrators of immune signaling.

Molecular biology of the cell·2026
Same author

Mechanoresilience of lysosomes conferred by TMEM63A.

The Journal of cell biology·2026
Same author

Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles.

Molecular biology of the cell·2026
Same author

Is the Parkinson's-associated protein TMEM175 a proton channel: Yay or nay?

The Journal of cell biology·2025
Same author

Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of apoptotic and bacterial extracellular vesicles.

Current biology : CB·2025
Same author

Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair.

Immunity·2025
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Nov 5, 2025

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes
11:01

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes

Published on: August 24, 2021

3.0K

Imagen instantánea: Macropinocitosis

Pedro E Marques1, Sergio Grinstein2, Spencer A Freeman1

  • 1Program in Cell Biology, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, 686 Bay Street, 19-9800, Toronto, ON M5G 0A4, Canada.

Cell
|May 6, 2017
PubMed
Resumen
Este resumen es generado por máquina.

La macropinocitosis, la captación de líquido en masa de las células, es vital para la vigilancia inmune. Este proceso también contribuye a la infección y la progresión del cáncer.

Más Videos Relacionados

Measuring the pH, Redox Chemistries, and Degradative Capacity of Macropinosomes using Dual-Fluorophore Ratiometric Microscopy
07:31

Measuring the pH, Redox Chemistries, and Degradative Capacity of Macropinosomes using Dual-Fluorophore Ratiometric Microscopy

Published on: August 19, 2021

2.6K
Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy
08:05

Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy

Published on: May 27, 2021

2.8K

Videos de Experimentos Relacionados

Last Updated: Nov 5, 2025

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes
11:01

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes

Published on: August 24, 2021

3.0K
Measuring the pH, Redox Chemistries, and Degradative Capacity of Macropinosomes using Dual-Fluorophore Ratiometric Microscopy
07:31

Measuring the pH, Redox Chemistries, and Degradative Capacity of Macropinosomes using Dual-Fluorophore Ratiometric Microscopy

Published on: August 19, 2021

2.6K
Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy
08:05

Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy

Published on: May 27, 2021

2.8K

Área de la Ciencia:

  • Biología celular
  • Inmunología
  • Patología

Sus antecedentes:

  • La macropinocitosis es un proceso celular que implica la absorción masiva de líquido extracelular a través de grandes vacíos endocíticos.
  • Este mecanismo juega un papel crucial en varios procesos fisiológicos, incluida la función de las células inmunes.

Objetivo del estudio:

  • Proporcionar una visión general de las funciones fisiológicas de la macropinocitosis.
  • Explorar las contribuciones patógenas de la macropinocitosis en los estados de enfermedad.

Principales métodos:

  • Análisis de la literatura sobre la macropinocitosis.
  • Análisis de la macropinocitosis en la vigilancia inmune.
  • Investigación de la macropinocitosis en la infección y el cáncer.

Principales resultados:

  • La macropinocitosis es esencial para la vigilancia inmune por parte de las células presentadoras de antígenos.
  • La macropinocitosis aberrante está implicada en la proliferación y supervivencia de las células cancerosas.
  • La macropinocitosis puede ser explotada por los patógenos para facilitar la infección.

Conclusiones:

  • La macropinocitosis es un proceso celular fundamental con un doble papel en la salud y la enfermedad.
  • Comprender la macropinocitosis ofrece objetivos terapéuticos potenciales para las infecciones y el cáncer.