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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
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Desenmascarar la actividad catalítica de un complejo de platino con un ligando de antimonio no inocente y ácido de
1Department of Chemistry, Texas A&M University , College Station, Texas 77843, United States.
Journal of the American Chemical Society
|May 10, 2017
Resumen
Los investigadores desarrollaron un catalizador de platino autoactivado con un ligando de antimonio ácido de Lewis. Este nuevo complejo cataliza eficientemente las reacciones de alquina como la ciclización de enyne y la hidroarilación a temperatura ambiente.
Área de la Ciencia:
- Química organometálica
- Catálisis
- Química del grupo principal
Sus antecedentes:
- El desarrollo de catalizadores electrofílicos autoactivados es crucial para una síntesis química eficiente.
- Las fracciones ácidas de Lewis cerca de los centros de metales de transición pueden mejorar la actividad catalítica.
Objetivo del estudio:
- Para sintetizar y caracterizar un nuevo complejo de platino con un centro de antimonio ácido de Lewis adyacente.
- Investigar el potencial catalítico de este complejo en las transformaciones orgánicas.
Principales métodos:
- Síntesis de un complejo platino-antimonio mediante el tratamiento de un precursor de platino con triflato de plata.
- Caracterización del complejo resultante.
- Evaluación del complejo como catalizador de las reacciones alquinosas, incluida la ciclización alquinosas y la hidroarilación intramolecular.
Principales resultados:
- Se sintetizó un complejo de platino estable, ((o-Ph2P) C6H4) 2SbOTf2) PtCl (2).
- El complejo 2 se somete a la abstracción de haluro intramolecular, activando el centro de platino.
- El complejo catalizó eficazmente las reacciones de ciclización y hidroarilación intramolecular a temperatura ambiente sin activadores externos.
Conclusiones:
- La no inocencia de coordinación de los ligandos de antimonio se puede utilizar para la catálisis electrofílica autoactivada.
- Este estudio presenta una nueva estrategia para el diseño de catalizadores de metales de transición eficientes y autoactivados.
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