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Glicopolímeros de respiración de azúcar para regular el nivel de glucosa
Yufen Xiao1, Hui Sun1, Jianzhong Du1,2
1Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University , 4800 Caoan Road, Shanghai 201804, China.
Journal of the American Chemical Society
|May 17, 2017
Resumen
Este estudio presenta una nueva nanoestructura de "esponja de azúcar" que regula los niveles de glucosa en la sangre sin insulina ni medicamentos. Este enfoque innovador ofrece un nuevo tratamiento potencial para la diabetes al imitar la regulación natural de la glucosa.
Área de la Ciencia:
- Ciencia de los biomateriales
- Nanotecnología
- Endocrinología
Sus antecedentes:
- La diabetes mellitus es una enfermedad crónica que requiere inyecciones diarias de insulina para la regulación de la glucosa en sangre.
- Los tratamientos actuales para la diabetes a menudo implican la administración frecuente de insulina, lo que supone una carga para los pacientes.
Objetivo del estudio:
- Desarrollar una estrategia sin insulina y sin medicamentos para la regulación de la glucosa en sangre utilizando una nueva nanoestructura.
- Investigar el potencial de un glicopolímero ligado a la lectina como agente terapéutico sensible a la glucosa.
Principales métodos:
- Autoensamblaje de un glicopolímero (PEO-b-P ((CMA-stat-DEA-stat-GEMA)) funcionalizado con lectina.
- Caracterización in vitro de la dinámica de unión y liberación de glucosa, incluidos los cambios de tamaño.
- Evaluación in vivo de la eficacia antidiabética en ratones diabéticos tipo I.
Principales resultados:
- El
- esponja de azúcar
- Se ha demostrado una absorción y liberación dinámicas de glucosa en función de la concentración.
- Se observaron cambios significativos de tamaño in vitro que indican una respuesta a la glucosa.
- Se logró un control efectivo de la glucosa en sangre en ratones diabéticos durante más de 2 días con una sola dosis.
Conclusiones:
- El glicopolímero ligado a la lectina actúa como un
- esponja de azúcar
- ofreciendo un nuevo enfoque para el control de la glucosa en sangre.
- Esta estrategia presenta una alternativa prometedora sin insulina y sin medicamentos para el tratamiento de la diabetes.
- El
- esponja de azúcar
- Este concepto abre nuevas vías terapéuticas para la diabetes mellitus.
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