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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
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Cadros orgánicos covalentes quirales multivariados con cristalinidad y estabilidad controladas para catálisis
Jie Zhang1, Xing Han1, Xiaowei Wu1
1State Key Laboratory of Metal Matrix Composites, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , Shanghai 200240, China.
Journal of the American Chemical Society
|May 25, 2017
Resumen
Los investigadores desarrollaron un nuevo método para crear marcos orgánicos covalentes quirales (CCOF) con estabilidad ajustable y cristalinidad para la catálisis asimétrica, logrando una alta selectividad en las reacciones clave.
Área de la Ciencia:
- Ciencias de los materiales
- Química orgánica
- Catálisis
Sus antecedentes:
- Los marcos orgánicos covalentes (COF) ofrecen una plataforma modular para materiales funcionales.
- El control sintético de la quiralidad de COF sigue siendo poco explorado.
- Los COF quirales (CCOF) son prometedores para la catálisis asimétrica.
Objetivo del estudio:
- Desarrollar una estrategia multivariada para la síntesis de COFs quirales (CCOF).
- Para lograr una cristalinidad y estabilidad controladas en los CCOF para la catálisis asimétrica.
- Investigar el impacto de la carga del catalizador en las propiedades del CCOF.
Principales métodos:
- Estrategia multivariada que incluye la cristalización de triaminas y dialdehídos con organocatalizadores quirales.
- Preparación de CCOF porosos 2D de dos y tres componentes con diferentes modos de apilamiento.
- Contenido de organocatalisador de afinación dentro de la estructura de COF.
Principales resultados:
- Se ha sintetizado con éxito una familia de CCOF porosos 2D con quiralidad, cristalinidad y estabilidad controladas.
- Los CCOF ternales mostraron una mayor cristalinidad y estabilidad en comparación con sus contrapartes binarias.
- Los CCOF ternales demostraron una alta eficiencia como catalizadores heterogéneos en las reacciones de aminoxilación asimétrica, aldol y Diels-Alder, con una selectividad que rivaliza con los catalizadores homogéneos.
Conclusiones:
- Se estableció una nueva ruta sintética para los CCOF con propiedades sintonizables.
- El estudio proporciona un método para controlar la cristalinidad y la estabilidad del COF a través del ajuste de componentes.
- Los CCOF desarrollados muestran un potencial significativo para la catálisis asimétrica heterogénea.
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