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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
La serología HTLV-III distingue entre el sarcoma de Kaposi atípico y el endémico en África
Lancet (London, England)
|February 16, 1985
Resumen
El retrovirus T linfotrópico humano tipo III (HTLV-III) se correlaciona fuertemente con el sarcoma atípico de Kaposi en pacientes africanos. Este hallazgo pone de relieve la aparición del HTLV-III como un factor significativo en los trastornos relacionados con el SIDA en África.
Área de la Ciencia:
- Virología Virología.
- Inmunología Inmunología.
- Oncología Oncología.
Sus antecedentes:
- El sarcoma de Kaposi (KS) se presenta de manera diferente en África, con formas clásicas endémicas y atípicas agresivas.
- Los trastornos relacionados con el síndrome de inmunodeficiencia adquirida (SIDA) están surgiendo en las poblaciones africanas.
Objetivo del estudio:
- Investigar la asociación entre los retrovirus linfotrópicos T humanos (HTLV) de los tipos I, II y III y los trastornos relacionados con KS/SIDA en pacientes africanos.
- Para comparar la seroprevalencia de HTLV en pacientes con diferentes formas de KS y controles sanos en Uganda y Zambia.
Principales métodos:
- Se probaron muestras de suero de pacientes africanos y sujetos normales para detectar anticuerpos contra HTLV-I, HTLV-II y HTLV-III.
- Las pruebas serológicas se realizaron en individuos de Uganda y Zambia.
Principales resultados:
- Casi el 90% de los pacientes con trastornos relacionados con el SIDA o KS atípico fueron seropositivos para HTLV-III.
- Solo el 17% de los pacientes con KS endémica clásica fueron seropositivos para HTLV-III.
- La seroprevalencia del HTLV-III en los controles fue del 20% en Uganda y del 2% en Zambia; no se detectaron anticuerpos contra el HTLV-I o el HTLV-II.
Conclusiones:
- La infección por HTLV-III está fuertemente asociada con el sarcoma de Kaposi atípico y agresivo y los trastornos relacionados con el SIDA en pacientes africanos.
- Los hallazgos sugieren que el HTLV-III es un patógeno relativamente nuevo en Zambia, potencialmente presente más tiempo en Uganda.
- La KS atípica en africanos se asemeja a la forma vista en pacientes estadounidenses con SIDA, vinculada al HTLV-III.
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