Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Base Excision Repair01:54

Base Excision Repair

26.9K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.9K
Protecting Groups for Aldehydes and Ketones: Introduction01:23

Protecting Groups for Aldehydes and Ketones: Introduction

9.3K
Protecting groups are compounds that can bind to a specific functional group in the presence of other functional groups to protect them from undesired chemical reactions. These compounds can selectively bind to particular functional groups and advance chemoselective reactions in polyfunctional systems (Figure 1). After the functional group has served its purpose, it is removed by reacting it with specific compounds.
9.3K
Mismatch Repair01:20

Mismatch Repair

6.8K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
6.8K
Mismatch Repair01:36

Mismatch Repair

44.1K
Overview
44.1K
Oxidations of Aldehydes and Ketones to Carboxylic Acids01:15

Oxidations of Aldehydes and Ketones to Carboxylic Acids

5.9K
Oxidation of aldehydes and ketones results in the formation of carboxylic acids. Aldehydes, bearing hydrogen next to the carbonyl group, are easily oxidized compared to ketones. This is because an aldehydic proton can easily be abstracted during oxidation.
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
5.9K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

2.1K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
2.1K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial.

JAMA network open·2026
Same author

PTEN deficiency confers sensitivity to ATR inhibitor-based treatment in high-grade serous ovarian cancer.

The Journal of clinical investigation·2026
Same author

USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality.

bioRxiv : the preprint server for biology·2026
Same author

HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by increasing PolΘ protein expression.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A Phase II Trial of Niraparib in Patients with Advanced Pancreatic Cancer Harboring Pathogenic Variants in ATM, BRCA1, BRCA2, PALB2, and CHEK2.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Lack of synergy between AR-targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America·2026

Video Experimental Relacionado

Updated: Mar 1, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

9.6K

Los aldehídos representan una amenaza para los portadores de la mutación BRCA2

Kalindi Parmar1, Alan D D'Andrea1

  • 1Department of Radiation Oncology and Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

Cell
|June 3, 2017
PubMed
Resumen

Los aldehídos ambientales pueden desencadenar cáncer en individuos con mutaciones BRCA2 al degradar las proteínas protectoras BRCA2, lo que lleva a la inestabilidad genómica. Este hallazgo aclara un paso clave en la carcinogénesis para estos individuos de alto riesgo.

Más Videos Relacionados

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.7K
Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

15.1K

Videos de Experimentos Relacionados

Last Updated: Mar 1, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

9.6K
gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.7K
Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

15.1K

Área de la Ciencia:

  • La bioquímica
  • La genética
  • Salud del medio ambiente

Sus antecedentes:

  • Las personas con mutaciones hereditarias heterocigóticas del BRCA2 enfrentan un mayor riesgo de cáncer.
  • Los desencadenantes específicos de la carcinogénesis en estos individuos siguen siendo en gran medida desconocidos.

Objetivo del estudio:

  • Investigar el papel de los aldehídos ambientales y metabólicos en el desarrollo del cáncer entre las personas con mutaciones BRCA2.
  • Elucidar los mecanismos moleculares que vinculan la exposición al aldehído con la predisposición al cáncer.

Principales métodos:

  • El estudio probablemente incluyó ensayos bioquímicos para evaluar la estabilidad de la proteína BRCA2.
  • Análisis de las respuestas celulares a la exposición al aldehído en el contexto de las mutaciones BRCA2.

Principales resultados:

  • Se encontró que los aldehídos ambientales y metabólicos promueven la degradación de la proteína BRCA2 de tipo salvaje.
  • Esta degradación de la proteína BRCA2 conduce a una mayor inestabilidad genómica.

Conclusiones:

  • Los aldehídos representan una amenaza ambiental y metabólica significativa para las personas con mutaciones BRCA2.
  • La degradación del BRCA2 inducida por el aldehído es un mecanismo potencial que predispone a estos individuos al cáncer.