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Pigmentos peptídicos poliméricos con propiedades codificadas por secuencia

Ayala Lampel1, Scott A McPhee1, Hang-Ah Park2

  • 1Advanced Science Research Center at the Graduate Center of the City University of New York, 85 Saint Nicholas Terrace, New York, NY 10031, USA.

Science (New York, N.Y.)
|June 10, 2017
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores desarrollaron pigmentos poliméricos sintonizables utilizando péptidos ricos en tirosina. La secuencia de péptidos controla las propiedades del pigmento como la protección UV y la coloración, lo que permite aplicaciones en cosméticos y biomedicina.

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Área de la Ciencia:

  • Ciencias de los biomateriales
  • Química de los polímeros
  • La biofísica

Sus antecedentes:

  • Las melaninas son biopolímeros versátiles que proporcionan protección UV, coloración y funciones antioxidantes.
  • Las propiedades de la melanina dependen de su compleja estructura polimérica y su desorden.
  • Los métodos actuales de síntesis de melanina carecen de un control preciso de las características del pigmento.

Objetivo del estudio:

  • Investigar el uso de trípeptidos que contienen tirosina como precursores sintéticos de las melaninas.
  • Para establecer un control dependiente de la secuencia sobre las propiedades del pigmento similar a la melanina.
  • Explorar las aplicaciones potenciales de estos pigmentos derivados de péptidos.

Principales métodos:

  • Tripeptídeos sintetizados que contienen tirosina con secuencias de aminoácidos definidas.
  • La polimerización oxidativa inducida de estos precursores del péptido.
  • Caracterizó los pigmentos poliméricos resultantes utilizando técnicas espectroscópicas, microscópicas y electroquímicas.

Principales resultados:

  • Logró un control dependiente de la secuencia sobre las propiedades del pigmento, incluida la absorción UV, la coloración y la morfología.
  • Se ha demostrado una actividad de eliminación de radicales libres y electroquímica ajustable.
  • Se observó una correlación entre la secuencia de péptidos y las características físicas y químicas del polímero resultante.

Conclusiones:

  • Los tripéptidos que contienen tirosina sirven como precursores efectivos y sintonizables para los pigmentos similares a la melanina.
  • La secuencia de péptidos ofrece una poderosa estrategia para la ingeniería de las propiedades del pigmento.
  • Estos pigmentos derivados de péptidos son prometedores para aplicaciones a corto plazo en cosméticos y biomedicina debido a la facilidad de síntesis y escalabilidad.