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Updated: Aug 15, 2026

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Isolation, Cryopreservation and Culture of Human Amnion Epithelial Cells for Clinical Applications
Published on: December 21, 2014
Un papel para el epitelio amniótico en el control del parto humano
Lancet (London, England)
|May 11, 1985
Resumen
Se encontró un inhibidor de la prostaglandina sintetasa asociado al embarazo (PAPSI) en el amnión antes del parto. Su ausencia durante el trabajo de parto establecido sugiere un papel para PAPSI en la iniciación del trabajo de parto a término.
Área de la Ciencia:
- Biología de la reproducción Biología reproductiva.
- La bioquímica es la bioquímica.
- Obstetrías y Obstetricia.
Sus antecedentes:
- Las prostaglandinas juegan un papel crucial en el inicio del trabajo de parto.
- La fuente y la regulación de las prostaglandinas en el embarazo humano no se comprenden completamente.
Objetivo del estudio:
- Para investigar la presencia y localización del inhibidor de la prostaglandina sintetasa asociado al embarazo (PAPSI) en el epitelio amniótico humano.
- Explorar el papel potencial de PAPSI en el inicio del trabajo a término.
Principales métodos:
- Se empleó la técnica de tinción antiperoxidasa peroxidasa-antiperoxidasa.
- Se recogieron muestras de epitelio amniótico humano de mujeres embarazadas a las 36-40 semanas de gestación, tanto antes como durante el parto establecido.
Principales resultados:
- PAPSI se detectó en las células epiteliales amnióticas de 12 de cada 15 mujeres antes del inicio del trabajo de parto.
- No se encontró PAPSI en el epitelio amniótico de 5 mujeres que estaban experimentando un parto clínicamente establecido.
Conclusiones:
- El amnión se identifica como una fuente de inhibidor endógeno de la prostaglandina sintetasa (PAPSI).
- La producción local de PAPSI del epitelio amniótico puede estar involucrada en el inicio del trabajo de parto a término.
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