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Updated: Feb 28, 2026

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
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Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

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Conformaciones emergentes ricas en hojas β en estructuras mutantes de exón 1 de huntingtina supercompacta

Hongsuk Kang1, Francisco X Vázquez1, Leili Zhang1

  • 1Computational Biology Center, IBM Thomas J. Watson Research Center , Yorktown Heights, New York 10598, United States.

Journal of the American Chemical Society
|June 14, 2017
PubMed
Resumen

La enfermedad de Huntington (HD) está relacionada con la poliglutamina (polyQ) en la proteína Huntingtin (Htt). Las simulaciones de dinámica molecular revelan que los tractos polyQ más largos forman estructuras supercompactas debido a las interacciones de la cadena lateral de la glutamina, lo que explica la patogénesis de la EH.

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