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Published on: June 12, 2009
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DAMed en (Trem) 2 etapas
Sandro Da Mesquita1, Jonathan Kipnis1
1Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Cell
|June 17, 2017
Resumen
Los investigadores identificaron una población única de microglia asociada a la enfermedad (DAM) que puede restringir el daño en la enfermedad de Alzheimer. Estas microglías se desarrollan en dos etapas distintas, ofreciendo nuevos conocimientos sobre la progresión de la enfermedad neurodegenerativa.
Área de la Ciencia:
- La neurociencia
- Inmunología
- Patología
Sus antecedentes:
- La función de la microglía, las células inmunes residentes del cerebro, en las enfermedades neurodegenerativas sigue siendo incompletamente entendida.
- Investigaciones anteriores han arrojado datos contradictorios con respecto al papel preciso de la microglía en afecciones como la enfermedad de Alzheimer.
Objetivo del estudio:
- Investigar los tipos y funciones específicas de la microglía implicadas en las enfermedades neurodegenerativas.
- Caracterizar un subconjunto microglial distinto potencialmente involucrado en la modulación de la enfermedad.
Principales métodos:
- Utilizó la secuenciación avanzada de ARN de una sola célula y el rastreo del linaje genético en modelos de ratón de la enfermedad de Alzheimer.
- Se realizaron análisis histológicos y moleculares para identificar y caracterizar poblaciones microgliales.
Principales resultados:
- Se identificó una nueva población de microglía, denominada microglía asociada a la enfermedad (DAM).
- Se ha demostrado que los DAM surgen a través de un proceso de activación en dos pasos.
- Se observó que los DAM están asociados con placas amiloides y pueden desempeñar un papel protector en las primeras etapas de la enfermedad.
Conclusiones:
- La microglía asociada a la enfermedad (DAM) representa un estado funcional específico de la microglía en la neurodegeneración.
- El desarrollo de dos pasos de DAM sugiere una respuesta regulada a los desencadenantes patológicos.
- Los DAM pueden servir como un objetivo terapéutico para mitigar la neuroinflamación y el daño neuronal en la enfermedad de Alzheimer y enfermedades relacionadas.
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