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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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El sarampión

William J Moss1

  • 1Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; International Vaccine Access Center, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

Lancet (London, England)
|July 5, 2017
PubMed
Resumen
Este resumen es generado por máquina.

El sarampión, una enfermedad viral contagiosa, causa más de 100.000 muertes al año. La vacunación reduce significativamente la incidencia y la mortalidad del sarampión, impulsando los esfuerzos hacia la erradicación global.

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Área de la Ciencia:

  • Virología
  • Epidemiología
  • Salud pública

Sus antecedentes:

  • El sarampión es una enfermedad viral altamente contagiosa transmitida por las vías respiratorias.
  • Causa una mortalidad global significativa, aunque reducida por la vacunación.
  • Las complicaciones, especialmente la neumonía, contribuyen a la morbilidad y la mortalidad.

Objetivo del estudio:

  • Revisar la epidemiología y el impacto del sarampión.
  • Destacar la importancia de la vacunación para el control y la erradicación del sarampión.
  • Discutir los desafíos actuales y las direcciones futuras en los esfuerzos de eliminación del sarampión.

Principales métodos:

  • Revisión de la literatura sobre la epidemiología, la presentación clínica y el manejo del sarampión.
  • Análisis de las tendencias mundiales de incidencia y mortalidad por sarampión.
  • Examen de las estrategias de vacunación y la investigación en curso.

Principales resultados:

  • La vacunación contra el sarampión ha reducido drásticamente las muertes de más de 2 millones a más de 100.000 al año.
  • La neumonía es una complicación importante que conduce a la morbilidad y mortalidad asociadas al sarampión.
  • La cobertura mundial de vacunación se ha estancado, lo que dificulta los esfuerzos de eliminación.

Conclusiones:

  • La prevención del sarampión a través de la vacunación es crucial para la eliminación regional y la erradicación global.
  • El refuerzo de los sistemas de inmunización de rutina y el aumento de la cobertura de la vacuna de dos dosis son esenciales.
  • Las innovaciones en el diagnóstico y los métodos de administración pueden acelerar el progreso hacia la erradicación del sarampión.