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In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
Published on: July 27, 2010
Leishmania donovani: un microbio oportunista asociado con la enfermedad progresiva en tres pacientes
Lancet (London, England)
|March 22, 1986
Resumen
La Leishmania donovani puede causar enfermedad grave y progresiva en individuos inmunocomprometidos. Esta infección parasitaria, la leishmaniasis, puede surgir años después de la exposición, destacando su naturaleza oportunista.
Área de la Ciencia:
- Enfermedades infecciosas Enfermedades infecciosas.
- Inmunología Inmunología.
- Parasitología Parasitología.
Sus antecedentes:
- Leishmania donovani es un parásito conocido por causar leishmaniasis visceral.
- Los huéspedes inmunocomprometidos son susceptibles a las infecciones oportunistas.
- La exposición previa a Leishmania donovani puede no conferir una inmunidad duradera.
Objetivo del estudio:
- Para describir casos de enfermedad Leishmania donovani progresiva en huéspedes inmunocomprometidos.
- Para resaltar el potencial de supervivencia a largo plazo de Leishmania donovani.
Principales métodos:
- Análisis del informe de caso de tres pacientes con leishmaniasis progresiva.
- Revisión de los antecedentes médicos de los pacientes, incluidas las terapias inmunosupresoras y las condiciones coexistentes.
Principales resultados:
- Tres pacientes inmunocomprometidos desarrollaron una leishmaniasis progresiva.
- Los pacientes estaban en terapias que incluían corticosteroides, ciclofosfamida y cloramfenicol.
- Dos casos involucraron a individuos que habían abandonado las áreas endémicas años antes, lo que sugiere la supervivencia a largo plazo del parásito.
Conclusiones:
- La Leishmania donovani puede causar enfermedad progresiva en huéspedes inmunocomprometidos.
- El parásito puede permanecer latente durante largos períodos en el huésped.
- La Leishmania donovani debe ser reconocida como un patógeno oportunista.
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