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El Factor Regulador de Interferón 5 controla la formación del núcleo necrótico en lesiones ateroscleróticas mediante

Anusha N Seneviratne1, Andreas Edsfeldt1, Jennifer E Cole1

  • 1From Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom (A.N.S., A.E., J.E.C., C.K., M.S., I.P., P.G., T.K., D.S., M.E.G., S.N.S., I.A.U., C.M.); Department of Bioengineering, Imperial College London, United Kingdom (A.N.S., R.K.); Experimental Cardiovascular Research Unit, Clinical Research Centre, Clinical Sciences Malmö, Lund University, Sweden (A.E., I.G.); Department of Cardiology, Skåne University Hospital, Lund/Malmö, Sweden (A.E., I.G.); and School of Engineering and Materials Science, Queen Mary University of London, United Kingdom (R.K.).

Circulation
|July 13, 2017
PubMed
Resumen

El factor regulador de interferón (IRF) 5 promueve la aterosclerosis mediante el mantenimiento de las células mieloides inflamatorias y la expansión de núcleos necróticos. La eliminación de IRF5 en ratones mejoró la eferocitosis y redujo el tamaño de la lesión, lo que sugiere que IRF5 es un objetivo terapéutico.

Palabras clave:
CD11cEl IRF5la aterosclerosisEfeerocitosisLos macrófagos

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