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Amplificación del oncogén c-erbB-2 en los adenocarcinomas humanos in vivo
Lancet (London, England)
|April 5, 1986
Resumen
El gen c-erbB-2 está amplificado en algunos adenocarcinomas, lo que sugiere un papel en su desarrollo. El gen receptor del factor de crecimiento epidérmico (EGF) (c-erbB-1) está amplificado en un pequeño número de carcinomas de células escamosas.
Área de la Ciencia:
- Biología Molecular Biología Molecular
- Oncología Oncología.
- Genética La genética.
Sus antecedentes:
- El genoma humano contiene dos genes relacionados con el gen viral erbB: c-erbB-1 (receptor del factor de crecimiento epidérmico) y c-erbB-2.
- c-erbB-2 codifica una proteína parecida a un receptor distinta del receptor del FEAG.
Objetivo del estudio:
- Investigar la amplificación de los genes de los receptores c-erbB-2 y c-erbB-1/EGF en tumores malignos humanos.
- Determinar el papel potencial de estos genes amplificados en tipos específicos de cáncer.
Principales métodos:
- El análisis de la hibridación del ADN se realizó en 101 tumores malignos humanos frescos.
- Los tumores fueron analizados para la amplificación génica de c-erbB-2 y c-erbB-1/EGF-receptor.
Principales resultados:
- El gen c-erbB-2 fue amplificado en 5 de los 63 adenocarcinomas.
- No se encontró amplificación de c-erbB-2 en otros 38 tipos de tumores.
- El gen del receptor c-erbB-1/EGF fue amplificado en 1 de cada 8 carcinomas de células escamosas.
Conclusiones:
- La amplificación del gen c-erbB-2 puede desempeñar un papel en la evolución de los adenocarcinomas.
- El gen receptor EGF puede estar involucrado en el desarrollo de algunos carcinomas de células escamosas.
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