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Relaxina sérica en el embarazo
Lancet (London, England)
|August 2, 1986
Resumen
Los niveles séricos de relaxina disminuyen al final del embarazo pero aumentan durante el parto. La relaxina más baja puede indicar riesgo de parto prematuro, mientras que los niveles más altos se observan en embarazos gemelos, lo que sugiere relaxina.
Área de la Ciencia:
- Endocrinología Reproductiva y Reproducción.
- La medicina materno-fetal es una de ellas.
- Regulación hormonal del embarazo.
Sus antecedentes:
- La relaxina sérica es una hormona clave en el embarazo.
- Su papel preciso en el inicio y progresión del trabajo de parto requiere una mayor aclaración.
Objetivo del estudio:
- Para investigar la inmunoactividad de la relaxina sérica en diferentes etapas del embarazo.
- Para correlacionar los niveles de relaxina con el parto espontáneo, el parto prematuro y los embarazos de gemelos.
Principales métodos:
- Estudio transversal de 302 embarazos individuales normales.
- Técnica de radioinmunoensayo utilizada para medir los niveles séricos de relaxina.
- Comparación de las concentraciones de relaxina a principios, mediados y terceros trimestres, durante el trabajo de parto y después del parto.
Principales resultados:
- Los niveles de relaxina en el tercer trimestre fueron más bajos que en el embarazo temprano/medio.
- Relaxina significativamente menor en el término en mujeres con inicio de parto espontáneo.
- Los niveles más altos de relaxina se observan durante el trabajo de parto, disminuyendo después del parto.
- Relaxina elevada en el tercer trimestre en embarazos gemelos en comparación con los singletons.
- Se observaron niveles bajos y decrecientes de relaxina en una paciente con parto prematuro.
Conclusiones:
- La relaxina sérica puede desempeñar un papel en el mantenimiento de la quiescencia miometrial.
- Relaxin facilita el crecimiento uterino y la maduración cervical.
- Los niveles de relaxina pueden potencialmente predecir el riesgo de parto prematuro y difieren en gestaciones múltiples.
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