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La evolución del microbioma huésped como un ecosistema en correa
Kevin R Foster1, Jonas Schluter2, Katharine Z Coyte1,2,3
1Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.
Nature
|August 4, 2017
Resumen
La teoría de la evolución nos ayuda a comprender el microbioma humano
Área de la Ciencia:
- Investigación del microbioma
- Biología evolutiva
- Interacciones huésped-micróbio
Sus antecedentes:
- El cuerpo humano alberga comunidades microbianas complejas con beneficios significativos.
- Comprender la biología del microbioma y sus impactos en la salud es un desafío.
- La teoría evolutiva ofrece un marco para el análisis del microbioma.
Objetivo del estudio:
- Para analizar las características del microbioma utilizando la teoría evolutiva.
- Para entender cómo evolucionan los huéspedes y los simbiontes.
- Explorar la interacción entre la competencia microbiana y el control del huésped.
Principales métodos:
- Aplicación de la teoría evolutiva a los estudios del microbioma.
- Analizando la co-evolución entre el huésped y el microbio.
- Investigar los mecanismos de control del huésped sobre las comunidades microbianas.
Principales resultados:
- Los simbiontes evolucionan para competir dentro del huésped.
- Los huéspedes desarrollan mecanismos para controlar el ecosistema microbiano.
- Los beneficios del microbioma surgen de la interacción de la competencia y el control.
Conclusiones:
- Los principios evolutivos son cruciales para comprender las funciones del microbioma.
- El control del huésped y la competencia microbiana dan forma a los beneficios para la salud del microbioma.
- Las investigaciones futuras deberían centrarse en esta interacción evolutiva.
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