Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.2K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.0K
Hematopoiesis01:21

Hematopoiesis

9.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
9.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.1K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.1K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

10.4K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
10.4K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Heterozygous <i>MMACHC</i> burden variants are associated with higher circulating vitamin B12 in the <i>All of Us</i> Research Program.

medRxiv : the preprint server for health sciences·2026
Same author

Hyperglycosylation is a metabolic driver of Alzheimer's disease.

Nature metabolism·2026
Same author

MitoSAM-dependent lipoylation controls postnatal heart development via metabolic remodeling.

bioRxiv : the preprint server for biology·2026
Same author

Follicular lymphoma with EBV-associated transformation, a single institution experience.

Annals of diagnostic pathology·2026
Same author

A local sympathetic-immune axis inhibits melanoma growth in mice by dictating adrenergic control.

Neuron·2026
Same author

Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer's brains.

Nature cell biology·2026
Same journal

Daily briefing: How cooperation built the world.

Nature·2026
Same journal

Deep-sea oddities and boatloads of other new species - June's best science images.

Nature·2026
Same journal

From cloning to gene-editing: the enduring legacy of Dolly the sheep.

Nature·2026
Same journal

Time to give hydration breaks the red card? What science says about keeping cool.

Nature·2026
Same journal

Universities are relying on AI-detection software to catch cheating. How well do the programs work?

Nature·2026
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
Ver todos los artículos relacionados
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: Feb 24, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
11:56

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

14.0K

El ascorbato regula la función de las células madre hematopoyéticas y la leucemogénesis

Michalis Agathocleous1, Corbin E Meacham1, Rebecca J Burgess1

  • 1Children's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Nature
|August 22, 2017
PubMed
Resumen
Este resumen es generado por máquina.

Las variaciones fisiológicas en los niveles de metabolitos regulan la función de las células madre. Los altos niveles de ascorbato en las células madre hematopoyéticas (HSC) limitan su frecuencia y función, mientras que el agotamiento acelera la leucemia.

Más Videos Relacionados

Modeling Chemotherapy Resistant Leukemia In Vitro
08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

9.6K
Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
09:44

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia

Published on: September 5, 2019

7.9K

Videos de Experimentos Relacionados

Last Updated: Feb 24, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
11:56

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

14.0K
Modeling Chemotherapy Resistant Leukemia In Vitro
08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

9.6K
Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
09:44

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia

Published on: September 5, 2019

7.9K

Área de la Ciencia:

  • La bioquímica
  • Biología celular
  • Hematología

Sus antecedentes:

  • El destino de las células madre está influenciado por los metabolitos en cultivo.
  • La regulación de la función de las células madre por variaciones fisiológicas de los metabolitos in vivo sigue sin estar clara.

Objetivo del estudio:

  • Investigar el papel de las variaciones fisiológicas de los metabolitos en la regulación de la función de las células madre in vivo.
  • Desarrollar un método metabolómico para analizar poblaciones de células raras directamente a partir de tejidos.

Principales métodos:

  • Desarrolló un nuevo método metabolómico para el análisis de poblaciones de células raras.
  • Comparación de las firmas metabólicas de las células madre hematopoyéticas de ratón (HSC) y de los progenitores.
  • Investigó los efectos del agotamiento sistémico del ascorbato en los HSC en ratones.

Principales resultados:

  • Se identificaron firmas metabólicas distintas para cada tipo de célula hematopoyética.
  • Los HSC exhibieron altos niveles de ascorbato, disminuyendo con la diferenciación.
  • El agotamiento del ascorbato aumentó la frecuencia y la función de los HSC, en parte mediante la inhibición del supresor tumoral Tet2.
  • El agotamiento del ascorbato aceleró la leucemogénesis mutada de Flt3, un efecto revertido por el ascorbato dietético.

Conclusiones:

  • La acumulación de ascorbato en los HSC promueve la actividad Tet, limitando la frecuencia de los HSC y suprimiendo la leucemogénesis.
  • El ascorbato regula negativamente la función HSC y la mielopoyesis a través de mecanismos independientes y dependientes de Tet2.
  • Los niveles de metabolitos, específicamente el ascorbato, juegan un papel crucial en la regulación de la función de las células madre y la prevención de la leucemia in vivo.